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Currently displaying 221 - 240 of 2495 publications

BPS2025 - Investigating α-synuclein liquid condensates transition to an irreversible aggregated state

IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles

Biophysical Journal

(2025)

124

79a

(doi: 10.1016/j.bpj.2024.11.489)

BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning

E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles

Biophysical Journal

(2025)

124

57a

(doi: 10.1016/j.bpj.2024.11.377)

BPS2025 - Single-molecule investigation of liquid-liquid and liquid-solid phase separation of amyloid proteins

M Sahu, J Wei, KV Vinoth, TP Knowles, K Garai

Biophysical Journal

(2025)

124

411a

(doi: 10.1016/j.bpj.2024.11.2208)

On the reversibility of amyloid fibril formation.

T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse

Biophys Rev (Melville)

(2025)

011303

(doi: 10.1063/5.0236947)

Competing addition processes give distinct growth regimes in the assembly of 1D filaments

SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit

Biophysical Journal

(2025)

124

778

(doi: 10.1016/j.bpj.2025.01.018)

Lipid-induced condensate formation from the Alzheimer’s Aβ peptide triggers amyloid aggregation

G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles

Proc Natl Acad Sci U S A

(2025)

122

e2401307122

(doi: 10.1073/pnas.2401307122)

Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

D Mazzali, G Rath, A Röntgen, V Roy Chowdhury, M Vendruscolo, M Resmini

Macromolecules

(2025)

1206

(doi: 10.1021/acs.macromol.4c02128)

Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins

S Errico, G Fani, S Ventura, J Schymkowitz, F Rousseau, A Trovato, M Vendruscolo, F Bemporad, F Chiti

Biochemical Journal

(2025)

482

(doi: 10.1042/bcj20240602)

Transient interactions between the fuzzy coat and the cross-beta core of brain-derived A-beta 42 filaments

M Milanesi, ZF Brotzakis, M Vendruscolo

Sci Adv

(2025)

eadr7008

(doi: 10.1126/sciadv.adr7008)

Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.

Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan

Nature Chemical Biology

(2025)

883

(doi: 10.1038/s41589-024-01811-1)

Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt

A Ramon, M Ni, O Predeina, R Gaffey, P Kunz, S Onuoha, P Sormanni

Mabs

(2025)

2442750

(doi: 10.1080/19420862.2024.2442750)

Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins

LW Browning, H Wang, JW Taylor, P Wilde, M Rodriguez-Garcia, LAM Holland, TPJ Knowles

Sustainable Food Technology

(2025)

689

(doi: 10.1039/d4fb00375f)

Estimation of Ligand Binding Free Energy Using Multi-eGO.

B Stegani, E Scalone, FB Toplek, T Löhr, S Gianni, M Vendruscolo, R Capelli, C Camilloni

J Chem Inf Model

(2024)

351

(doi: 10.1021/acs.jcim.4c01545)

G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability.

IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti

Mol Cell

(2024)

585

(doi: 10.1016/j.molcel.2024.11.039)

Liquid-liquid phase separation in hepatocellular carcinoma

J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang

Frontiers in Cell and Developmental Biology

(2024)

1454587

(doi: 10.3389/fcell.2024.1454587)

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.

N Watamura, MS Foiani, S Bez, M Bourdenx, A Santambrogio, C Frodsham, E Camporesi, G Brinkmalm, H Zetterberg, S Patel, N Kamano, M Takahashi, J Rueda-Carrasco, L Katsouri, S Fowler, E Turkes, S Hashimoto, H Sasaguri, T Saito, AS Islam, S Benner, T Endo, K Kobayashi, C Ishida, M Vendruscolo, M Yamada, KE Duff, TC Saido

Nat Neurosci

(2024)

293

(doi: 10.1038/s41593-024-01829-7)

Ultra-sensitive protein aggregate quantification assays for neurodegenerative diseases on the Simoa platform

D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman

Anal Chem

(2024)

290

(doi: 10.1021/acs.analchem.4c04188)

Proteostasis Signatures in Human Diseases

CM Lim, M Vendruscolo