Centre for Misfolding Diseases

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  • Currently displaying 301 - 320 of 2403 publications
Author(s)
Publication title
Journal Name
Publication year
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α‑Synuclein at Physiological pH with Sodium Salts
RI Horne, MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, G Meisl, M Vendruscolo
ACS Chem Neurosci
(2023)
14
(doi: 10.1021/acschemneuro.3c00282)
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions
M Kar, LT Vogel, G Chauhan, H Ausserwöger, TJ Welsh, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
(2023)
(doi: 10.1101/2023.08.11.552963)
Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, ZF Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
(2023)
(doi: 10.1101/2023.08.09.552642)
Targeted protein modification with an antibody-based system
O Rimon, J Konc, M Ali, VR Chowdhury, I Černauskienė, P Sormanni, GJL Bernardes, M Vendruscolo
(2023)
(doi: 10.1101/2023.07.28.551006)
Electrophysiological In Vitro Study of Long-Range Signal Transmission by Astrocytic Networks
N Hastings, Y-L Yu, B Huang, S Middya, M Inaoka, NA Erkamp, RJ Mason, A Carnicer-Lombarte, S Rahman, TPJ Knowles, M Bance, GG Malliaras, MRN Kotter
Adv Sci (Weinh)
(2023)
10
(doi: 10.1002/advs.202301756)
Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy.
Z Faidon Brotzakis, T Löhr, S Truong, S Hoff, M Bonomi, M Vendruscolo
Biochemistry
(2023)
62
(doi: 10.1021/acs.biochem.3c00010)
Single-molecule digital sizing of proteins in solution
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, F-U Hartl, SF Lee, TPJ Knowles
(2023)
(doi: 10.1101/2023.07.12.548675)
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes.
S Errico, G Lucchesi, D Odino, EY Osman, R Cascella, L Neri, C Capitini, M Calamai, F Bemporad, C Cecchi, WA Kinney, D Barbut, A Relini, C Canale, G Caminati, R Limbocker, M Vendruscolo, M Zasloff, F Chiti
Journal of Medicinal Chemistry
(2023)
66
(doi: 10.1021/acs.jmedchem.3c00182)
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
(2023)
(doi: 10.1101/2023.07.05.547777)
Amyloid formation as a protein phase transition
TCT Michaels, D Qian, A Šarić, M Vendruscolo, S Linse, TPJ Knowles
Nature Reviews Physics
(2023)
5
(doi: 10.1038/s42254-023-00598-9)
Amyloids and protein aggregation
S Linse, T Knowles
Chemical Science
(2023)
14
(doi: 10.1039/d2sc90225g)
Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics.
DB Morse, AM Michalowski, M Ceribelli, J De Jonghe, M Vias, D Riley, T Davies-Hill, T Voss, S Pittaluga, C Muus, J Liu, S Boyle, DA Weitz, JD Brenton, JD Buenrostro, TPJ Knowles, CJ Thomas
Cell Systems
(2023)
14
(doi: 10.1016/j.cels.2023.05.003)
Extracellular protein homeostasis: The dawning of a new age for human disease therapies?
MR Wilson, S Satapathy, M Vendruscolo
Clin Transl Med
(2023)
13
(doi: 10.1002/ctm2.1305)
Formation of Protein Nanoparticles in Microdroplet Flow Reactors
Q Zhang, Z Toprakcioglu, AK Jayaram, G Guo, X Wang, TPJ Knowles
ACS nano
(2023)
17
(doi: 10.1021/acsnano.3c00107)
Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics.
KT Pang, YS Yang, W Zhang, YS Ho, P Sormanni, TCT Michaels, I Walsh, S Chia
Biotechnology advances
(2023)
67
(doi: 10.1016/j.biotechadv.2023.108192)
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, L Tatalick, P Ruivo, MP de Miranda, A Gomes, T Carvalho, MJ Walker, H Ausserwoeger, J Pedro Simas, M Veldhoen, TPJ Knowles, D-A Silva, D Shoultz, GJL Bernardes
The Journal of infectious diseases
(2023)
228
(doi: 10.1093/infdis/jiad135)
Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation.
M Vendruscolo
Expert Opinion on Drug Discovery
(2023)
18
(doi: 10.1080/17460441.2023.2221024)
Quantifying collective interactions in biomolecular phase separation
H Ausserwöger, D Qian, G Krainer, E de Csilléry, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
(2023)
(doi: 10.1101/2023.05.31.543137)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
Angewandte Chemie
(2023)
135
(doi: 10.1002/ange.202304449)
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.
S Koga, MA Metrick, LI Golbe, A Santambrogio, M Kim, AI Soto-Beasley, RL Walton, MC Baker, CF De Castro, M DeTure, D Russell, BA Navia, C Sandiego, OA Ross, M Vendruscolo, B Caughey, DW Dickson
Acta neuropathologica communications
(2023)
11
(doi: 10.1186/s40478-023-01584-z)
Yusuf Hamied Department of Chemistry
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