Centre for Misfolding Diseases

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  • Currently displaying 301 - 320 of 2449 publications
Author(s)
Publication title
Journal Name
Publication year
Improving Antibody Humanness Prediction using Patent Data
T Ucar, A Ramon, D Oglic, R Croasdale-Wood, T Diethe, P Sormanni
(2024)
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity
RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, RC Gregory, A Possenti, S Chia, M Vendruscolo
Journal of chemical information and modeling
(2024)
64
(doi: 10.1021/acs.jcim.3c01777)
The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation
G Šneiderienė, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
(2024)
(doi: 10.1101/2024.01.14.575549)
Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV
A Ramon, M Ali, M Atkinson, A Saturnino, K Didi, C Visentin, S Ricagno, X Xu, M Greenig, P Sormanni
Nature Machine Intelligence
(2024)
6
(doi: 10.1038/s42256-023-00778-3)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
M Milanesi, ZF Brotzakis, M Vendruscolo
(2024)
(doi: 10.1101/2024.01.08.574772)
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1.
G Lopes Bernardes
Chembiochem
(2024)
25
(doi: 10.1002/cbic.202300736)
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy.
A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, M Hosmillo, IG Goodfellow, R Kollyfas, R Doffinger, JR Bradley, II Mohorianu, R Jones, TPJ Knowles, R Smith, V Kosmoliaptsis
Front Immunol
(2024)
14
(doi: 10.3389/fimmu.2023.1296148)
Secondary pathways cause the proliferation of amyloid aggregates of medin, an aortic medial amyloid peptide associated with cerebral amyloid angiopathy
VR Chowdhury, RI Horne, AG Diaz, M Vendruscolo
FEBS OPEN BIO
(2024)
14
Effects of α-synuclein proteoforms on the liquid-liquid phase separation and aggregation of α-synuclein
A Rontgen, Z Toprakcioglu, S Dada, O Morris, M Vendruscolo
FEBS OPEN BIO
(2024)
14
Aggregate-binding aptamers for Parkinson's disease diagnostics
M Nowinska, J Chovas, M Donde, M Canzano, M Vendruscolo
FEBS OPEN BIO
(2024)
14
Optimizing performance characteristics of antibodies for single-molecule quantitative bioimaging
JC Breiter, C Loiseau, JS Beckwith, R Andrews, B Fu, PJ Magill, SF Lee, M Vendruscolo
FEBS OPEN BIO
(2024)
14
Kinetics and thermodynamics characterization of serum amyloid A (SAA) protein
H Nadwa, A Santucci, D Braconi, F Brotzakis, M Vendruscolo
FEBS OPEN BIO
(2024)
14
Effects of aminosterols and berberine on the structural and dynamical properties of biological membranes against the action of misfolded protein oligomers
S Errico, G Lucchesi, D Odino, R Cascella, C Capitini, M Vendruscolo, M Zasloff, F Chiti
FEBS OPEN BIO
(2024)
14
Machine Learning Uncovers Natural Product Modulators of the 5‑Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms
S Mikutis, S Lawrinowitz, C Kretzer, L Dunsmore, L Sketeris, T Rodrigues, O Werz, GJL Bernardes
ACS Chemical Biology
(2023)
19
(doi: 10.1021/acschembio.3c00725)
Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation
OM Morris, Z Toprakcioglu, A Röntgen, M Cali, TPJ Knowles, M Vendruscolo
(2023)
(doi: 10.1101/2023.12.23.573169)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St. George-Hyslop, FS Ruggeri, TPJ Knowles, M Vendruscolo
(2023)
(doi: 10.1101/2023.12.21.572955)
Monoclonal antibodies targeting cytotoxic α-synuclein oligomers: molecular properties and diagnostic potential
D Otzen, J Nielsen, J Lauritsen, J Pedersen, J Nowak, M Bendtsen, G Kleijwegt, M Schneider, G Krainer, T Knowles, L Goksøyr, P Khalifé, S Kaalund, S Aznar, M Kjærgaard, M Nielsen, F Sander, M Romero-Ramos
(2023)
(doi: 10.21203/rs.3.rs-3778118/v1)
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors
R Chandra, RI Horne, M Vendruscolo
J Chem Theory Comput
(2023)
20
(doi: 10.1021/acs.jctc.3c01224)
Nonspecificity fingerprints for clinical-stage antibodies in solution
TW Herling, G Invernizzi, H Ausserwöger, JR Bjelke, T Egebjerg, S Lund, N Lorenzen, TPJ Knowles
Proceedings of the National Academy of Sciences
(2023)
120
(doi: 10.1073/pnas.2306700120)
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
B Fu, EE Brock, R Andrews, JC Breiter, R Tian, CE Toomey, J Lachica, T Lashley, M Ryten, NW Wood, M Vendruscolo, S Gandhi, LE Weiss, JS Beckwith, SF Lee
(2023)
(doi: 10.1101/2023.12.18.572148)
Yusuf Hamied Department of Chemistry
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