Centre for Misfolding Diseases

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  • Currently displaying 321 - 340 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
α-Synuclein oligomers form by secondary nucleation
CK Xu, G Meisl, E Andrzejewska, G Krainer, AJ Dear, MC Cruz, S Turi, R Jacquat, WE Arter, M Vendruscolo, S Linse, TP Knowles
(2023)
(doi: 10.1101/2023.05.28.542651)
Label-free detection of proteins with optofluidic hollow-core photonic crystal fibre sensors
JR Heck, E Miele, R Mouthaan, MH Frosz, TPJ Knowles, TG Euser
SPIE Future Sensing Technologies 2023
(2023)
12327
(doi: 10.1117/12.2643905)
Towards sequence-based principles for protein phase separation predictions.
M Vendruscolo, M Fuxreiter
Curr Opin Chem Biol
(2023)
75
(doi: 10.1016/j.cbpa.2023.102317)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
Proceedings of the National Academy of Sciences of USA
(2023)
120
(doi: 10.1073/pnas.2216234120)
Theoretical and Data-Driven Approaches for Biomolecular Condensates
KL Saar, D Qian, LL Good, AS Morgunov, R Collepardo-Guevara, RB Best, TPJ Knowles
Chem Rev
(2023)
123
(doi: 10.1021/acs.chemrev.2c00586)
O010 A novel microfluidic immunoassay for in-solution quantification of alloantibody affinity and concentration in transplantation and beyond
A Priddey, G Karahan, M Schneider, G Meisl, T Scheidt, C Xu, S Peacock, R Buchli, A Mulder, S Heidt, F Class, T Knowles, V Kosmolipaptsis
British Journal of Surgery
(2023)
110
(doi: 10.1093/bjs/znad101.010)
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions.
GM Dal Forno, E Latocheski, A Beatriz Machado, J Becher, L Dunsmore, AL St John, BL Oliveira, CD Navo, G Jiménez-Osés, R Fior, JB Domingos, GJL Bernardes
J Am Chem Soc
(2023)
145
(doi: 10.1021/jacs.3c01960)
AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering
A Ramon, M Ali, M Atkinson, A Saturnino, K Didi, C Visentin, S Ricagno, X Xu, M Greenig, P Sormanni
(2023)
(doi: 10.1101/2023.04.28.538712)
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules
S Mikutis, M Rebelo, E Yankova, M Gu, C Tang, AR Coelho, M Yang, ME Hazemi, M Pires de Miranda, M Eleftheriou, M Robertson, GS Vassiliou, DJ Adams, JP Simas, F Corzana, JS Schneekloth, K Tzelepis, GJL Bernardes
ACS Cent Sci
(2023)
9
(doi: 10.1021/acscentsci.3c00015)
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
R Limbocker, N Cremades, R Cascella, PM Tessier, M Vendruscolo, F Chiti
Acc Chem Res
(2023)
56
(doi: 10.1021/acs.accounts.3c00045)
Maturation-Dependent Changes in the Structure and Seeding Capacity of Aβ42 Amyloid Fibrils
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
(2023)
(doi: 10.1101/2023.04.11.536374)
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
Nature Communications
(2023)
14
(doi: 10.1038/s41467-023-37668-6)
Surface patches induce nonspecific binding and phase separation of antibodies
H Ausserwöger, G Krainer, TJ Welsh, N Thorsteinson, E de Csilléry, T Sneideris, MM Schneider, T Egebjerg, G Invernizzi, TW Herling, N Lorenzen, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2023)
120
(doi: 10.1073/pnas.2210332120)
The amyloid-β pathway in Alzheimer's disease: a plain language summary.
H Hampel, Y Hu, J Hardy, K Blennow, C Chen, G Perry, SH Kim, VL Villemagne, P Aisen, M Vendruscolo, T Iwatsubo, CL Masters, M Cho, L Lannfelt, JL Cummings, A Vergallo
Neurodegener Dis Manag
(2023)
13
(doi: 10.2217/nmt-2022-0037)
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins
A Hatos, JMC Teixeira, S Barrera-Vilarmau, A Horvath, SCE Tosatto, M Vendruscolo, M Fuxreiter
Nucleic Acids Research
(2023)
51
(doi: 10.1093/nar/gkad214)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
bioRxiv
(2023)
(doi: 10.1101/2023.03.22.533832)
Sequence-based prediction of the solubility of peptides containing non-natural amino acids
M Oeller, R Kang, H Bolt, AGD Santos, A Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
(2023)
(doi: 10.21203/rs.3.rs-2661708/v1)
α-synuclein oligomers displace monomeric α-synuclein from lipid membranes
G Šneiderienė, MA Czekalska, CK Xu, A Jayaram, G Krainer, WE Arter, Q Peter, M Castellana-Cruz, KL Saar, A Levin, T Mueller, S Fiedler, SRA Devenish, H Fiegler, JR Kumita, TPJ Knowles
(2023)
(doi: 10.1101/2023.03.21.533646)
AlphaFold Prediction of Structural Ensembles of Disordered Proteins
ZF Brotzakis, S Zhang, M Vendruscolo
(2023)
(doi: 10.21203/rs.3.rs-2659892/v1)
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α‑Synuclein Secondary Nucleation
RI Horne, MH Murtada, D Huo, ZF Brotzakis, RC Gregory, A Possenti, S Chia, M Vendruscolo
Journal of Chemical Theory and Computation
(2023)
19
(doi: 10.1021/acs.jctc.2c01303)
Yusuf Hamied Department of Chemistry
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