Centre for Misfolding Diseases

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  • Currently displaying 281 - 300 of 2400 publications
Author(s)
Publication title
Journal Name
Publication year
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
Proceedings of the National Academy of Sciences
(2023)
120
(doi: 10.1073/pnas.2216234120)
Theoretical and Data-Driven Approaches for Biomolecular Condensates.
KL Saar, D Qian, LL Good, AS Morgunov, R Collepardo-Guevara, RB Best, TPJ Knowles
Chemical Reviews
(2023)
123
(doi: 10.1021/acs.chemrev.2c00586)
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions
GM Dal Forno, E Latocheski, A Beatriz Machado, J Becher, L Dunsmore, AL St John, BL Oliveira, CD Navo, G Jiménez-Osés, R Fior, JB Domingos, GJL Bernardes
J Am Chem Soc
(2023)
145
(doi: 10.1021/jacs.3c01960)
AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering
A Ramon, M Ali, M Atkinson, A Saturnino, K Didi, C Visentin, S Ricagno, X Xu, M Greenig, P Sormanni
(2023)
(doi: 10.1101/2023.04.28.538712)
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.
S Mikutis, M Rebelo, E Yankova, M Gu, C Tang, AR Coelho, M Yang, ME Hazemi, M Pires de Miranda, M Eleftheriou, M Robertson, GS Vassiliou, DJ Adams, JP Simas, F Corzana, JS Schneekloth, K Tzelepis, GJL Bernardes
ACS central science
(2023)
9
(doi: 10.1021/acscentsci.3c00015)
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
R Limbocker, N Cremades, R Cascella, PM Tessier, M Vendruscolo, F Chiti
Accounts of Chemical Research
(2023)
56
(doi: 10.1021/acs.accounts.3c00045)
Automated optimisation of solubility and conformational stability of antibodies and proteins.
P Sormanni, A Rosace, A Bennett, M Oeller, M Mortensen, L Sakhnini, N Lorenzen, C Poulsen
Nat Commun
(2023)
14
(doi: 10.1038/s41467-023-37668-6)
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
Nature Communications
(2023)
14
(doi: 10.1038/s41467-023-37668-6)
The amyloid-β Pathway in Alzheimer’s Disease: A Plain Language Summary
H Hampel, Y Hu, J Hardy, K Blennow, C Chen, G Perry, SH Kim, VL Villemagne, P Aisen, M Vendruscolo, T Iwatsubo, CL Masters, M Cho, L Lannfelt, JL Cummings, A Vergallo
Neurodegenerative disease management
(2023)
13
(doi: 10.2217/nmt-2022-0037)
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins.
A Hatos, JMC Teixeira, S Barrera-Vilarmau, A Horvath, SCE Tosatto, M Vendruscolo, M Fuxreiter
Nucleic acids research
(2023)
51
(doi: 10.1093/nar/gkad214)
Sequence-based prediction of the solubility of peptides containing non-natural amino acids
M Oeller, R Kang, H Bolt, AGD Santos, A Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
(2023)
(doi: 10.21203/rs.3.rs-2661708/v1)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
bioRxiv
(2023)
(doi: 10.1101/2023.03.22.533832)
AlphaFold Prediction of Structural Ensembles of Disordered Proteins
F Brotzakis, S Zhang, M Vendruscolo
(2023)
(doi: 10.21203/rs.3.rs-2659892/v1)
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α‑Synuclein Secondary Nucleation
RI Horne, MH Murtada, D Huo, ZF Brotzakis, RC Gregory, A Possenti, S Chia, M Vendruscolo
Journal of chemical theory and computation
(2023)
19
(doi: 10.1021/acs.jctc.2c01303)
Multidimensional Protein Solubility Optimization with an Ultrahigh- Throughput Microfluidic Platform
NA Erkamp, M Oeller, T Sneideris, H Ausserwoger, A Levin, TJ Welsh, R Qi, D Qian, N Lorenzen, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles
Analytical chemistry
(2023)
95
(doi: 10.1021/acs.analchem.2c05495)
Kinetic Analysis Reveals the Role of Secondary Nucleation in Regenerated Silk Fibroin Self-Assembly
A Kamada, Z Toprakcioglu, TPJ Knowles
Biomacromolecules
(2023)
24
(doi: 10.1021/acs.biomac.2c01479)
Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum
MM Schneider, T Scheidt, AJ Priddey, CK Xu, M Hu, G Meisl, SRA Devenish, CM Dobson, V Kosmoliaptsis, TPJ Knowles
Biosensors and Bioelectronics
(2023)
228
(doi: 10.1016/j.bios.2023.115196)
Sequence-based prediction of the solubility of peptides containing non-natural amino acids
M Oeller, R Kang, H Bolt, A Gomes dos Santos, A Langborg Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
(2023)
(doi: 10.1101/2023.03.03.530952)
Single-Molecule Sizing through Nanocavity Confinement
RPB Jacquat, G Krainer, QAE Peter, AN Babar, O Vanderpoorten, CK Xu, TJ Welsh, CF Kaminski, UF Keyser, JJ Baumberg, TPJ Knowles
Nano Letters
(2023)
23
(doi: 10.1021/acs.nanolett.1c04830)
Extracellular protein homeostasis in neurodegenerative diseases.
MR Wilson, S Satapathy, M Vendruscolo
Nature reviews. Neurology
(2023)
19
(doi: 10.1038/s41582-023-00786-2)
Yusuf Hamied Department of Chemistry
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