Centre for Misfolding Diseases

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  • Currently displaying 281 - 300 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids.
M Oeller, RJD Kang, HL Bolt, AL Gomes Dos Santos, AL Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
Nat Commun
(2023)
14
(doi: 10.1038/s41467-023-42940-w)
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
Journal of the American Chemical Society
(2023)
145
(doi: 10.1021/jacs.3c09335)
Linking modulation of bio-molecular phase behaviour with collective interactions
D Qian, H Ausserwoger, WE Arter, RM Scrutton, TJ Welsh, T Kartanas, N Ermann, S Qamar, C Fischer, T Sneideris, P St George-Hyslop, RV Pappu, TPJ Knowles
(2023)
(doi: 10.1101/2023.11.02.565376)
Droplet dynamics in asymmetric microfluidic junctions
H Yang, Y Xu, T Knowles
European Journal of Mechanics B Fluids
(2023)
102
(doi: 10.1016/j.euromechflu.2023.07.011)
Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres-Mozas, T Rodrigues, G Jiménez-Osés, GJL Bernardes
Angew Chem Int Ed Engl
(2023)
62
(doi: 10.1002/anie.202311186)
Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres‐Mozas, T Rodrigues, G Jiménez‐Osés, GJL Bernardes
Angewandte Chemie
(2023)
135
(doi: 10.1002/ange.202311186)
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD-20 therapy
A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, M Hosmillo, IG Goodfellow, R Kollyfas, R Doffinger, JR Bradley, II Mohorianu, R Jones, TPJ Knowles, R Smith, V Kosmoliaptsis
(2023)
(doi: 10.1101/2023.10.22.563481)
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, N Harper, K Yahya, TCT Michaels, S Linse, TPJ Knowles, X Yang, SC Brewerton, J Thomson, J Habchi, G Meisl
(2023)
(doi: 10.1101/2023.10.20.563279)
Score-Based Generative Models for Designing Binding Peptide Backbones
JD Boom, M Greenig, P Sormanni, P Liò
(2023)
Multi-omic prediction of therapeutic targets for human diseases associated with protein phase separation
M Vendruscolo, C Lim, A González Díaz, M Fuxreiter, F Pun, A Zhavoronkov
Proceedings of the National Academy of Sciences of USA
(2023)
(doi: 10.1073/pnas.2300215120)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
M Vendruscolo, S Dada, Z Toprakcioglu, M Hardenberg, M Cali, L Mrugalla, O Morris, A Roentgen, T Knowles
(2023)
(doi: 10.21203/rs.3.rs-3174399/v1)
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions
M Kar, LT Vogel, G Chauhan, H Ausserwöger, TJ Welsh, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
(2023)
(doi: 10.21203/rs.3.rs-3252197/v1)
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
C Olivieri, Y Wang, C Walker, MV Subrahmanian, KN Ha, DA Bernlohr, J Gao, C Camilloni, M Vendruscolo, SS Taylor, G Veglia
bioRxiv
(2023)
4
(doi: 10.1101/2023.09.12.557419)
Ganglioside Lipids Inhibit the Aggregation of the Alzheimer’s Related Peptide Amyloid-β
Z Toprakcioglu, AK Jayaram, TPJ Knowles
(2023)
(doi: 10.1101/2023.09.10.556751)
Effects of Processing-Induced Contamination on Organic Electronic Devices.
D Simatos, IE Jacobs, I Dobryden, M Nguyen, A Savva, D Venkateshvaran, M Nikolka, J Charmet, LJ Spalek, M Gicevičius, Y Zhang, G Schweicher, DJ Howe, S Ursel, J Armitage, IB Dimov, U Kraft, W Zhang, M Alsufyani, I McCulloch, RM Owens, PM Claesson, TPJ Knowles, H Sirringhaus
Small methods
(2023)
7
(doi: 10.1002/smtd.202300476)
Optimization of a small molecule inhibitor of secondary nucleation in a-synuclein aggregation
R Staats, ZF Brotzakis, S Chia, RI Horne, M Vendruscolo
Frontiers in molecular biosciences
(2023)
10
(doi: 10.3389/fmolb.2023.1155753)
Thermodynamic profiles for co-translational trigger factor function
TW Herling, AME Cassaignau, AS Wentink, QAE Peter, PC Kumar, T Kartanas, MM Schneider, LD Cabrita, J Christodoulou, TPJ Knowles
(2023)
(doi: 10.1101/2023.08.23.554456)
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJD Gonzalez, NR Bennett, P Venkatesh, D Satoe, M Ahlrichs, C Dobbins, W Yang, X Wang, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, GJL Bernardes, KT Roybal, P Greisen, X Li, C Bertozzi, D Baker
bioRxiv
(2023)
4
(doi: 10.1101/2023.08.19.553321)
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α‑Synuclein at Physiological pH with Sodium Salts
RI Horne, MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, G Meisl, M Vendruscolo
ACS chemical neuroscience
(2023)
14
(doi: 10.1021/acschemneuro.3c00282)
Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, ZF Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
(2023)
(doi: 10.1101/2023.08.09.552642)
Yusuf Hamied Department of Chemistry
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