Centre for Misfolding Diseases

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  • Currently displaying 261 - 280 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Sequence-Based Drug Design Using Transformers
M Vendruscolo, S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan
(2024)
(doi: 10.21203/rs.3.rs-3682847/v1)
Imaging Aβ aggregation by liquid-phase transmission electron microscopy
G Ing, S Acosta-Gutiérrez, M Vendruscolo, G Battaglia, L Ruiz-Pérez
(2024)
(doi: 10.1101/2024.01.29.577710)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
M Vendruscolo, M Milanesi, ZF Brotzakis
(2024)
(doi: 10.21203/rs.3.rs-3847495/v1)
Improving Antibody Humanness Prediction using Patent Data
T Ucar, A Ramon, D Oglic, R Croasdale-Wood, T Diethe, P Sormanni
(2024)
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity.
RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, RC Gregory, A Possenti, S Chia, M Vendruscolo
Journal of chemical information and modeling
(2024)
64
(doi: 10.1021/acs.jcim.3c01777)
Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV
A Ramon, M Ali, M Atkinson, A Saturnino, K Didi, C Visentin, S Ricagno, X Xu, M Greenig, P Sormanni
Nature Machine Intelligence
(2024)
6
(doi: 10.1038/s42256-023-00778-3)
The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation
G Šneiderienė, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
(2024)
(doi: 10.1101/2024.01.14.575549)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
M Milanesi, ZF Brotzakis, M Vendruscolo
(2024)
(doi: 10.1101/2024.01.08.574772)
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1.
G Lopes Bernardes
ChemBioChem: a European journal of chemical biology
(2024)
25
(doi: 10.1002/cbic.202300736)
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy
A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, M Hosmillo, IG Goodfellow, R Kollyfas, R Doffinger, JR Bradley, II Mohorianu, R Jones, TPJ Knowles, R Smith, V Kosmoliaptsis
Frontiers in Immunology
(2024)
14
(doi: 10.3389/fimmu.2023.1296148)
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms
S Mikutis, S Lawrinowitz, C Kretzer, L Dunsmore, L Sketeris, T Rodrigues, O Werz, GJL Bernardes
ACS chemical biology
(2023)
19
(doi: 10.1021/acschembio.3c00725)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St. George-Hyslop, FS Ruggeri, TPJ Knowles, M Vendruscolo
(2023)
(doi: 10.1101/2023.12.21.572955)
Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation
OM Morris, Z Toprakcioglu, A Röntgen, M Cali, TPJ Knowles, M Vendruscolo
(2023)
(doi: 10.1101/2023.12.23.573169)
Monoclonal antibodies targeting cytotoxic α-synuclein oligomers: molecular properties and diagnostic potential
D Otzen, J Nielsen, J Lauritsen, J Pedersen, J Nowak, M Bendtsen, G Kleijwegt, M Schneider, G Krainer, T Knowles, L Goksøyr, P Khalifé, S Kaalund, S Aznar, M Kjærgaard, M Nielsen, F Sander, M Romero-Ramos
(2023)
(doi: 10.21203/rs.3.rs-3778118/v1)
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors
R Chandra, RI Horne, M Vendruscolo
J Chem Theory Comput
(2023)
20
(doi: 10.1021/acs.jctc.3c01224)
Nonspecificity fingerprints for clinical-stage antibodies in solution.
TW Herling, G Invernizzi, H Ausserwöger, JR Bjelke, T Egebjerg, S Lund, N Lorenzen, TPJ Knowles
Proceedings of the National Academy of Sciences
(2023)
120
(doi: 10.1073/pnas.2306700120)
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
B Fu, EE Brock, R Andrews, JC Breiter, R Tian, CE Toomey, J Lachica, T Lashley, M Ryten, NW Wood, M Vendruscolo, S Gandhi, LE Weiss, JS Beckwith, SF Lee
(2023)
(doi: 10.1101/2023.12.18.572148)
Sequence-based drug design using transformers
S Zhang, D Huo, RI Horne, Y Qi, SP Ojeda, A Yan, M Vendruscolo
(2023)
(doi: 10.1101/2023.11.27.568880)
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses.
IA Bermejo, A Guerreiro, A Eguskiza, N Martínez-Sáez, FS Lazaris, A Asín, VJ Somovilla, I Compañón, TK Raju, S Tadic, P Garrido, J García-Sanmartín, V Mangini, AS Grosso, F Marcelo, A Avenoza, JH Busto, F García-Martín, R Hurtado-Guerrero, JM Peregrina, GJL Bernardes, A Martínez, R Fiammengo, F Corzana
JACS Au
(2023)
4
(doi: 10.1021/jacsau.3c00587)
CryoENsemble - a Bayesian approach for reweighting biomolecular structural ensembles using heterogeneous cryo-EM maps
T Włodarski, JO Streit, A Mitropoulou, LD Cabrita, M Vendruscolo, J Christodoulou
(2023)
(doi: 10.1101/2023.11.21.567999)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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