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Centre for Misfolding Diseases

Dr Simone Ruggeri

Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.



In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.


For a complete list of publications please see below:

Publications

Sequence-Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons
C Schilling, T Mack, S Lickfett, S Sieste, FS Ruggeri, T Sneideris, A Dutta, T Bereau, R Naraghi, D Sinske, TPJ Knowles, CV Synatschke, T Weil, B Knöll
– Advanced Functional Materials
(2019)
29,
1809112
(doi: 10.1002/adfm.201809112)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nat Commun
(2019)
10,
1541
(doi: 10.1038/s41467-019-09477-3)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
– Macromolecular Rapid Communications
(2019)
40,
e1800898
(doi: 10.1002/marc.201800898)
Atomic force microscopy for single molecule characterisation of protein aggregation
FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
– Archives of Biochemistry and Biophysics
(2019)
664,
134
(doi: 10.1016/j.abb.2019.02.001)
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– Analyst
(2019)
144,
4413
(doi: 10.1039/c9an00382g)
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Chemical Neuroscience
(2018)
9,
2959
(doi: 10.1021/acschemneuro.8b00141)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
– Nature Communications
(2018)
9,
3890
(doi: 10.1038/s41467-018-06345-4)
Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes
Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang
– Acta biomaterialia
(2018)
78,
111
(doi: 10.1016/j.actbio.2018.08.010)
N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.
SM DeGuire, FS Ruggeri, M-B Fares, A Chiki, U Cendrowska, G Dietler, HA Lashuel
– Journal of Biological Chemistry
(2018)
293,
18540
(doi: 10.1074/jbc.ra118.004621)
Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy
FS Ruggeri, C Marcott, S Dinarelli, G Longo, M Girasole, G Dietler, TPJ Knowles
– International Journal of Molecular Sciences
(2018)
19,
E2582
(doi: 10.3390/ijms19092582)
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Telephone number

01223 763845 (shared)

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