Dr Simone Ruggeri

Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.

In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.

For a complete list of publications please see below:

Publications

Sequence‐Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons

C Schilling, T Mack, S Lickfett, S Sieste, FS Ruggeri, T Sneideris, A Dutta, T Bereau, R Naraghi, D Sinske, TPJ Knowles, CV Synatschke, T Weil, B Knöll

Advanced Functional Materials

(2019)

1809112

(doi: 10.1002/adfm.201809112)

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman

Nature Communications

(2019)

1541

(doi: 10.1038/s41467-019-09477-3)

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules

X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles

Macromolecular rapid communications

(2019)

e1800898

(doi: 10.1002/marc.201800898)

Atomic force microscopy for single molecule characterisation of protein aggregation

FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles

Archives of biochemistry and biophysics

(2019)

664

134

(doi: 10.1016/j.abb.2019.02.001)

Stabilization and Characterization of Cytotoxic Aβ₄₀ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo

ACS Chem Neurosci

(2018)

2959

(doi: 10.1021/acschemneuro.8b00141)

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.

FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles

Nature Communications

(2018)

3890

(doi: 10.1038/s41467-018-06345-4)

Solution Fibre Spinning Technique for the Fabrication of Tuneable Decellularised Matrix-Laden Fibres and Fibrous Micromembranes

Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang

Acta biomaterialia

(2018)

111

(doi: 10.1016/j.actbio.2018.08.010)

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

SM DeGuire, FS Ruggeri, M-B Fares, A Chiki, U Cendrowska, G Dietler, HA Lashuel

The Journal of biological chemistry

(2018)

293

18540

(doi: 10.1074/jbc.RA118.004621)

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy.

FS Ruggeri, C Marcott, S Dinarelli, G Longo, M Girasole, G Dietler, TPJ Knowles

International Journal of Molecular Sciences

(2018)

2582

(doi: 10.3390/ijms19092582)

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler

Proceedings of the National Academy of Sciences

(2018)

115

7230

(doi: 10.1073/pnas.1721220115)

Dr Simone Ruggeri

Research Associate

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