Dr Simone Ruggeri

Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.

In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.

For a complete list of publications please see below:

Publications

Ultrathin Polydopamine Films with Phospholipid Nanodiscs Containing a Glycophorin A Domain

T Marchesi D'Alvise, S Harvey, L Hueske, J Szelwicka, L Veith, TPJ Knowles, D Kubiczek, C Flaig, F Port, KE Gottschalk, F Rosenau, B Graczykowski, G Fytas, FS Ruggeri, K Wunderlich, T Weil

Advanced Functional Materials

(2020)

2000378

(doi: 10.1002/adfm.202000378)

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, MN Bongiovanni, TPJ Knowles, CM Dobson

ACS nano

(2020)

5213

(doi: 10.1021/acsnano.9b09676)

Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on α-synuclein amyloid formation

J Zhou, FS Ruggeri, MR Zimmermann, G Meisl, G Longo, SK Sekatskii, TPJ Knowles, G Dietler

Chem Sci

(2020)

3687

(doi: 10.1039/d0sc00281j)

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers.

SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, R Cascella, CM Dobson, M Vendruscolo, TPJ Knowles, F Chiti

Biomacromolecules

(2020)

1112

(doi: 10.1021/acs.biomac.9b01475)

Trodusquemine enhances Aβ

R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson

Nature communications

(2019)

225

(doi: 10.1038/s41467-018-07699-5)

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles

JoVE

(2019)

2019

ARTN e60108

(doi: 10.3791/60108)

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo

(2019)

729392

(doi: 10.1101/729392)

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman

Acta neuropathologica communications

(2019)

120

(doi: 10.1186/s40478-019-0777-4)

Infrared nanospectroscopic mapping of a single metaphase chromosome

E Lipiec, FS Ruggeri, C Benadiba, AM Borkowska, JD Kobierski, J Miszczyk, BR Wood, GB Deacon, A Kulik, G Dietler, WM Kwiatek

Nucleic Acids Research

(2019)

e108

(doi: 10.1093/nar/gkz630)

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis.

MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles

Analyst

(2019)

144

4413

(doi: 10.1039/c9an00382g)

Dr Simone Ruggeri

Research Associate

Publications

Postdoctoral researcher

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Research at Cambridge