Dr Simone Ruggeri

Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.

In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.

For a complete list of publications please see below:

Publications

Determination of Polypeptide Conformation with Nanoscale Resolution in Water.

G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone

ACS nano

(2018)

6612

(doi: 10.1021/acsnano.8b01425)

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler

Proceedings of the National Academy of Sciences of the United States of America

(2018)

115

7230

(doi: 10.1073/pnas.1721220115)

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

Nature chemistry

(2018)

673

(doi: 10.1038/s41557-018-0031-x)

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop

Cell

(2018)

173

720

(doi: 10.1016/j.cell.2018.03.056)

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion

S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll

Adv Healthc Mater

(2018)

e1701485

(doi: 10.1002/adhm.201701485)

Molecular determinants of the interaction of EGCG with ordered and disordered proteins.

G Fusco, M Sanz-Hernandez, FS Ruggeri, M Vendruscolo, CM Dobson, A De Simone

Biopolymers

(2018)

109

e23117

(doi: 10.1002/bip.23117)

Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy

FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles

Biophysical Journal

(2018)

114

224a

(doi: 10.1016/j.bpj.2017.11.1246)

Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates

R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson

Biophysical Journal

(2018)

114

430A

(doi: 10.1016/j.bpj.2017.11.2382)

Nanoscale infrared spectroscopy and imaging of aging red blood cells

C Marcott, S Ruggeri

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2018)

255

Amyloid single-cell cytotoxicity assays by nanomotion detection.

FS Ruggeri, A-L Mahul-Mellier, S Kasas, HA Lashuel, G Longo, G Dietler

Cell death discovery

(2017)

17053

(doi: 10.1038/cddiscovery.2017.53)

Dr Simone Ruggeri

Research Associate

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