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Centre for Misfolding Diseases

Dr Simone Ruggeri

Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.



In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.


For a complete list of publications please see below:

Publications

Determination of Polypeptide Conformation with Nanoscale Resolution in Water
G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone
– ACS nano
(2018)
12,
6612
(doi: 10.1021/acsnano.8b01425)
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.
FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
7230
(doi: 10.1073/pnas.1721220115)
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nat Chem
(2018)
10,
673
(doi: 10.1038/s41557-018-0031-x)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop
– Cell
(2018)
173,
720
(doi: 10.1016/j.cell.2018.03.056)
Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.
S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll
– Adv Healthc Mater
(2018)
7,
e1701485
(doi: 10.1002/adhm.201701485)
Molecular determinants of the interaction of EGCG with ordered and disordered proteins
G Fusco, M Sanz-Hernandez, FS Ruggeri, M Vendruscolo, CM Dobson, A De Simone
– Biopolymers
(2018)
109,
e23117
(doi: 10.1002/bip.23117)
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2018)
114,
430a
(doi: 10.1016/j.bpj.2017.11.2382)
Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
– Biophysical Journal
(2018)
114,
224A
(doi: 10.1016/j.bpj.2017.11.1246)
Nanoscale infrared spectroscopy and imaging of aging red blood cells
C Marcott, S Ruggeri
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
255,
(link to publication)
Amyloid single-cell cytotoxicity assays by nanomotion detection.
FS Ruggeri, A-L Mahul-Mellier, S Kasas, HA Lashuel, G Longo, G Dietler
– Cell death discovery
(2017)
3,
17053
(doi: 10.1038/cddiscovery.2017.53)
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Postdoctoral researcher

Telephone number

01223 763845 (shared)

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