Centre for Misfolding Diseases

Francesco Aprile

Senior Research Fellow

Publications

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.
JB Bertoldo, T Rodrigues, L Dunsmore, FA Aprile, MC Marques, LA Rosado, O Boutureira, TB Steinbrecher, W Sherman, F Corzana, H Terenzi, GJL Bernardes
Chem
(2017)
3
(doi: 10.1016/j.chempr.2017.07.009)
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, M Vendruscolo
Journal of Molecular Biology
(2017)
429
(doi: 10.1016/j.jmb.2017.07.016)
Methods of probing the interactions between small molecules and disordered proteins.
GT Heller, FA Aprile, M Vendruscolo
Cellular and molecular life sciences : CMLS
(2017)
74
(doi: 10.1007/s00018-017-2563-4)
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
F aprile, E Källstig, G Limorenko, Vendruscolo, D Ron, C hansen
Scientific Reports
(2017)
7
(doi: 10.1038/s41598-017-08324-z)
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
Sci Adv
(2017)
3
(doi: 10.1126/sciadv.1700488)
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
O Sin, T de Jong, A Mata-Cabana, M Kudron, MA Zaini, FA Aprile, RI Seinstra, E Stroo, RW Prins, CN Martineau, HH Wang, W Hogewerf, A Steinhof, EE Wanker, M Vendruscolo, CF Calkhoven, V Reinke, V Guryev, EAA Nollen
Mol Cell
(2017)
65
(doi: 10.1016/j.molcel.2017.02.022)
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
Biochemistry
(2017)
56
(doi: 10.1021/acs.biochem.6b01178)
Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
Proceedings of the National Academy of Sciences
(2017)
114
(doi: 10.1073/pnas.1701964114)
A natural product inhibits the initiation of α-synuclein aggregation & suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
Proceedings of the National Academy of Sciences of the United States of America
(2017)
114
(doi: 10.1073/pnas.1610586114)
Structure of a low-population binding intermediate in protein-RNA recognition
AN Borkar, MF Bardaro, C Camilloni, FA Aprile, G Varani, M Vendruscolo
Proc Natl Acad Sci U S A
(2016)
113
(doi: 10.1073/pnas.1521349113)

Research Staff Scientist

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01223 763845 (shared), 01223 763842
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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