Senior Research Fellow

Publications

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.
FA Aprile, P Sormanni, M Vendruscolo
Biochemistry
(2015)
54
Cell surface localised Hsp70 is a cancer specific regulator of clathrin‐independent endocytosis
B Nimmervoll, LA Chtcheglova, K Juhasz, N Cremades, FA Aprile, A Sonnleitner, P Hinterdorfer, L Vigh, J Preiner, Z Balogi
FEBS Letters
(2015)
589
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
P Sormanni, FA Aprile, M Vendruscolo
Proceedings of the National Academy of Sciences
(2015)
112
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
Proceedings of the National Academy of Sciences
(2015)
112
Structure and Dynamics of the Integrin LFA-1 I-Domain in the Inactive State Underlie its Inside-Out/Outside-In Signaling and Allosteric Mechanisms
P Kukic, HT Alvin Leung, F Bemporad, FA Aprile, JR Kumita, A De Simone, C Camilloni, M Vendruscolo
Structure (London, England : 1993)
(2015)
23
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
Journal of Molecular Biology
(2015)
427
Structure of a low-population intermediate state in the release of an enzyme product
A De Simone, FA Aprile, A Dhulesia, CM Dobson, M Vendruscolo
Elife
(2015)
4
Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
PROTEIN SCIENCE
(2015)
24
Rapid sizing of proteins in complex solutions
P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Chemical communications (Cambridge, England)
(2015)
51

Research Staff Scientist

Telephone number

01223 763842, 01223 763845 (shared)