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Centre for Misfolding Diseases

Senior Research Fellow

Publications

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
– Anal Chem
(2016)
88,
3488
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS nano
(2015)
10,
333
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.
FA Aprile, P Sormanni, M Vendruscolo
– Biochemistry
(2015)
54,
5103
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis.
B Nimmervoll, LA Chtcheglova, K Juhasz, N Cremades, FA Aprile, A Sonnleitner, P Hinterdorfer, L Vigh, J Preiner, Z Balogi
– FEBS Lett
(2015)
589,
2747
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.
P Sormanni, FA Aprile, M Vendruscolo
– Proc Natl Acad Sci U S A
(2015)
112,
9902
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences
(2015)
112,
e1994
Structure and Dynamics of the Integrin LFA-1 I-Domain in the Inactive State Underlie its Inside-Out/Outside-In Signaling and Allosteric Mechanisms
P Kukic, HT Alvin Leung, F Bemporad, FA Aprile, JR Kumita, A De Simone, C Camilloni, M Vendruscolo
– Structure
(2015)
23,
745
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
– Journal of Molecular Biology
(2015)
427,
478
Structure of a low-population intermediate state in the release of an enzyme product.
A De Simone, FA Aprile, A Dhulesia, CM Dobson, M Vendruscolo
– Elife
(2015)
4,
e02777
Rapid sizing of proteins in complex solutions
P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S49
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Research Staff Scientist

Telephone number

01223 763845 (shared)