Dr Anthony Coyne

Publications

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis

P Gupta, S Thomas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, A Coyne, W Jacobs, T Blundell, S Tiwari, V Mendes

(2021)

(doi: 10.1101/2021.03.12.435067)

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, T Moschetti, AR Bayly, TD Sharpe, KT Haas, L Barber, CR Valenzano, R Srinivasan, DJ Huggins, M Lee, A Emery, B Hardwick, M Ehebauer, C Dagostin, A Esposito, L Pellegrini, T Perrior, G McKenzie, TL Blundell, M Hyvönen, J Skidmore, AR Venkitaraman, C Abell

Cell Chem Biol

(2021)

835

(doi: 10.1016/j.chembiol.2021.02.006)

Chris Abell 1957–2020

FJ Leeper, AG Coyne

Biochemist

(2021)

(doi: 10.1042/bio_2021_106)

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, N Nahiyaan, S O'Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell

Nat Commun

(2021)

143

(doi: 10.1038/s41467-020-20224-x)

Bicyclic 5-5 Systems: Three Heteroatoms 1:2

AG Coyne

(2021)

(doi: 10.1016/b978-0-12-409547-2.14914-5)

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

J El Bakali, M Blaszczyk, J Evans, J Boland, W McCarthy, M Dias, A Coyne, V Mizrahi, T Blundell, C Abell, C Spry

(2020)

2020.09.04.280388

(doi: 10.1101/2020.09.04.280388)

Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.

M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell

J Med Chem

(2020)

8650

(doi: 10.1021/acs.jmedchem.0c01187)

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

D Scott, N Francis-Newton, M Marsh, A Coyne, G Fischer, T Moschetti, A Bayly, T Sharpe, K Haas, L Barber, C Valenzano, R Srinivasan, D Huggins, M Ehebauer, A Esposito, L Pellegrini, T Perrior, G McKenzie, T Blundell, M Hyvönen, J Skidmore, A Venkitaraman, C Abell

(2020)

(doi: 10.1101/2020.07.15.200709)

Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis

JA Ribeiro, A Hammer, GA Libreros-Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, J El Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias

ACS infectious diseases

(2020)

2192

(doi: 10.1021/acsinfecdis.0c00263)

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.

SE Thomas, AJ Whitehouse, K Brown, S Burbaud, JM Belardinelli, J Sangen, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes

Nucleic Acids Res

(2020)

8099

(doi: 10.1093/nar/gkaa539)

Dr Anthony Coyne

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About the Department

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Research at Cambridge