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Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference
J El Bakali, M Blaszczyk, J Evans, J Boland, W McCarthy, M Dias, A Coyne, V Mizrahi, T Blundell, C Abell, C Spry
(2020)
2020.09.04.280388
(doi: 10.1101/2020.09.04.280388)
Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell
– Journal of medicinal chemistry
(2020)
63,
8650
(doi: 10.1021/acs.jmedchem.0c01187)
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
D Scott, N Francis-Newton, M Marsh, A Coyne, G Fischer, T Moschetti, A Bayly, T Sharpe, K Haas, L Barber, C Valenzano, R Srinivasan, D Huggins, M Ehebauer, A Esposito, L Pellegrini, T Perrior, G McKenzie, T Blundell, M Hyvönen, J Skidmore, A Venkitaraman, C Abell
(2020)
(doi: 10.1101/2020.07.15.200709)
Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
JA Ribeiro, A Hammer, GA Libreros-Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, J El Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias
– ACS Infect Dis
(2020)
6,
2192
(doi: 10.1021/acsinfecdis.0c00263)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
SE Thomas, AJ Whitehouse, K Brown, S Burbaud, JM Belardinelli, J Sangen, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
– Nucleic Acids Res
(2020)
48,
8099
(doi: 10.1093/nar/gkaa539)
Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell
– J Med Chem
(2020)
63,
4749
(doi: 10.1021/acs.jmedchem.0c00007)
Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis
JA Ribeiro, A Hammer, GA Libreros Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, JE Bakali, SA Rocco, ML Sforça, R Parise-Filho, A Coyne, T Blundell, C Abell, MV Bertacine Dias
(2020)
(doi: 10.1101/2020.03.30.016204)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, TL Blundell, C Abell
(2020)
(doi: 10.26434/chemrxiv.10280849)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, R Vistal, D Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, T Blundell, C Abell
(2020)
(doi: 10.26434/chemrxiv.10280849.v2)
InhibitingMycobacterium tuberculosisCoaBC by targeting a new allosteric site
V Mendes, S Green, J Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, S O’Neill, S Damerow, J Post, T Bayliss, S Lynch, A Coyne, P Ray, C Abell, K Rhee, H Boshoff, C Barry, V Mizrahi, P Wyatt, T Blundell
(2019)
(doi: 10.1101/870154)
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01223 336055

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