Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway ofMycobacterium tuberculosis
P Gupta, SE Thomas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, AG Coyne, WR Jacobs, TL Blundell, S Tiwari, V Mendes
(2021)
(doi: 10.1101/2021.03.12.435067)
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, T Moschetti, AR Bayly, TD Sharpe, KT Haas, L Barber, CR Valenzano, R Srinivasan, DJ Huggins, M Lee, A Emery, B Hardwick, M Ehebauer, C Dagostin, A Esposito, L Pellegrini, T Perrior, G McKenzie, TL Blundell, M Hyvönen, J Skidmore, AR Venkitaraman, C Abell
Cell chemical biology
(2021)
28
(doi: 10.1016/j.chembiol.2021.02.006)
Chris Abell 1957–2020
FJ Leeper, AG Coyne
Biochemist
(2021)
43
(doi: 10.1042/BIO_2021_106)
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site
V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, N Nahiyaan, S O'Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell
Nature communications
(2021)
12
(doi: 10.1038/s41467-020-20224-x)
Bicyclic 5-5 Systems: Three Heteroatoms 1:2
AG Coyne
(2021)
(doi: 10.1016/B978-0-12-409547-2.14914-5)
Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference
JE Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, MVB Dias, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
(2020)
(doi: 10.1101/2020.09.04.280388)
Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell
J Med Chem
(2020)
63
(doi: 10.1021/acs.jmedchem.0c01187)
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, T Moschetti, AR Bayly, TD Sharpe, KT Haas, L Barber, CR Valenzano, R Srinivasan, DJ Huggins, M Ehebauer, A Esposito, L Pellegrini, T Perrior, G McKenzie, TL Blundell, M Hyvönen, J Skidmore, AR Venkitaraman, C Abell
(2020)
(doi: 10.1101/2020.07.15.200709)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
SE Thomas, AJ Whitehouse, K Brown, S Burbaud, JM Belardinelli, J Sangen, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
Nucleic Acids Res
(2020)
48
(doi: 10.1093/nar/gkaa539)
Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
JA Ribeiro, A Hammer, GA Libreros-Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, J El Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias
ACS Infectious Diseases
(2020)
6
(doi: 10.1021/acsinfecdis.0c00263)

Postdoctoral researcher

Email address

agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge