Dr Anthony Coyne | Centre for Misfolding Diseases

Publications

Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors

M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, TL Blundell, C Abell

(2020)

(doi: 10.26434/chemrxiv.10280849)

Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors

M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, TL Blundell, C Abell

(2020)

(doi: 10.26434/chemrxiv.10280849.v2)

InhibitingMycobacterium tuberculosisCoaBC by targeting a new allosteric site

V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, S O’Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell

(2019)

(doi: 10.1101/870154)

Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.

RC Panicker, S Chattopadhaya, AG Coyne, R Srinivasan

Advances in Experimental Medicine and Biology

(2019)

1163

253

(doi: 10.1007/978-981-13-8719-7_11)

Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors

M Sabbah, V Mendes, RG Vistal, DMG Dias, J Korduláková, K Mikušová, A Coyne, TL Blundell, C Abell

(2019)

(doi: 10.26434/chemrxiv.10280849.v1)

Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).

A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne

Bioorganic & Medicinal Chemistry Letters

(2019)

30

126792

(doi: 10.1016/j.bmcl.2019.126792)

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode.

AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell

J Med Chem

(2019)

62

10586

(doi: 10.1021/acs.jmedchem.9b01203)

Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.

DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell

Biochemical Journal

(2019)

476

3125

(doi: 10.1042/BCJ20190318)

The Application of Fragment-based Approaches to the Discovery of Drugs for Neglected Tropical Diseases

C Spry, AG Coyne

(2019)

18

(doi: 10.1201/9781351011655-2)

Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?

RC Panicker, AG Coyne, R Srinivasan

Current medicinal chemistry

(2019)

26

2234

(doi: 10.2174/0929867324666170727120315)