Publications

Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis
JA Ribeiro, A Hammer, GA Libreros Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, JE Bakali, SA Rocco, ML Sforça, R Parise-Filho, A Coyne, T Blundell, C Abell, MV Bertacine Dias
(2020)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, R Vistal, D Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, T Blundell, C Abell
(2020)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, TL Blundell, C Abell
(2020)
Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site
V Mendes, S Green, J Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, S O’Neill, S Damerow, J Post, T Bayliss, S Lynch, A Coyne, P Ray, C Abell, K Rhee, H Boshoff, C Barry, V Mizrahi, P Wyatt, T Blundell
(2019)
Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors
RC Panicker, S Chattopadhaya, AG Coyne, R Srinivasan
Adv Exp Med Biol
(2019)
1163
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, R Vistal, D Dias, J Korduláková, K Mikušová, A Coyne, T Blundell, C Abell
(2019)
Covalent inactivation of Mycobacterium thermoresistibile inosine-5′-monophosphate dehydrogenase (IMPDH)
A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne
Bioorganic and Medicinal Chemistry Letters
(2019)
30
Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
Journal of medicinal chemistry
(2019)
62
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
Biochemical Journal
(2019)
476
The Application of Fragment-based Approaches to the Discovery of Drugs for Neglected Tropical Diseases
C Spry, AG Coyne
(2019)

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01223 336055

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