Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) fromMycobacterium tuberculosis
JA Ribeiro, A Hammer, GAL Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, JE Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias
(2020)
(doi: 10.1101/2020.03.30.016204)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, TL Blundell, C Abell
(2020)
(doi: 10.26434/chemrxiv.10280849.v2)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, TL Blundell, C Abell
(2020)
(doi: 10.26434/chemrxiv.10280849)
Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site
V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, S O’Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell
(2019)
(doi: 10.1101/870154)
Allosteric small-molecule serine/threonine kinase inhibitors
RC Panicker, S Chattopadhaya, AG Coyne, R Srinivasan
Advances in experimental medicine and biology
(2019)
1163
(doi: 10.1007/978-981-13-8719-7_11)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, J Korduláková, K Mikušová, A Coyne, TL Blundell, C Abell
(2019)
(doi: 10.26434/chemrxiv.10280849.v1)
Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).
A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne
Bioorganic & Medicinal Chemistry Letters
(2019)
30
(doi: 10.1016/j.bmcl.2019.126792)
Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
J Med Chem
(2019)
62
(doi: 10.1021/acs.jmedchem.9b01203)
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
Biochemical Journal
(2019)
476
(doi: 10.1042/BCJ20190318)
The Application of Fragment-based Approaches to the Discovery of Drugs for Neglected Tropical Diseases
C Spry, AG Coyne
(2019)
(doi: 10.1201/9781351011655-2)

Postdoctoral researcher

Email address

agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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