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Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
S Charoensutthivarakul, SE Thomas, A Curran, KP Brown, JM Belardinelli, AJ Whitehouse, M Acebrón-García-de-Eulate, J Sangan, SG Gramani, M Jackson, V Mendes, RA Floto, TL Blundell, AG Coyne, C Abell
– ACS Infectious Diseases
(2022)
8,
296
(doi: 10.1021/acsinfecdis.1c00432)
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
M Frederickson, IR Selvam, D Evangelopoulos, KJ McLean, MM Katariya, RB Tunnicliffe, B Campbell, ME Kavanagh, S Charoensutthivarakul, RT Blankley, CW Levy, LPS de Carvalho, D Leys, AW Munro, AG Coyne, C Abell
– European Journal of Medicinal Chemistry
(2022)
230,
114105
(doi: 10.1016/j.ejmech.2022.114105)
10.02 Bicyclic 5-5 Systems: Three Heteroatoms 1:2
AG Coyne
(2022)
41
(doi: 10.1016/b978-0-12-409547-2.14914-5)
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis
P Gupta, SE Thomas, SA Zaidan, MA Pasillas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, AG Coyne, WR Jacobs, TL Blundell, S Tiwari, V Mendes
– Comput Struct Biotechnol J
(2021)
19,
3491
(doi: 10.1016/j.csbj.2021.06.006)
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl- l -cysteine Synthetase (CoaB) Activity
JC Evans, D Murugesan, JM Post, V Mendes, Z Wang, N Nahiyaan, SL Lynch, S Thompson, SR Green, PC Ray, J Hess, C Spry, AG Coyne, C Abell, HIM Boshoff, PG Wyatt, KY Rhee, TL Blundell, CE Barry, V Mizrahi
– ACS infectious diseases
(2021)
7,
1666
(doi: 10.1021/acsinfecdis.0c00904)
A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis
P Gupta, S Thomas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, A Coyne, W Jacobs, T Blundell, S Tiwari, V Mendes
(2021)
(doi: 10.1101/2021.03.12.435067)
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, T Moschetti, AR Bayly, TD Sharpe, KT Haas, L Barber, CR Valenzano, R Srinivasan, DJ Huggins, M Lee, A Emery, B Hardwick, M Ehebauer, C Dagostin, A Esposito, L Pellegrini, T Perrior, G McKenzie, TL Blundell, M Hyvönen, J Skidmore, AR Venkitaraman, C Abell
– Cell chemical biology
(2021)
28,
835
(doi: 10.1016/j.chembiol.2021.02.006)
Chris Abell 1957–2020
FJ Leeper, AG Coyne
– Biochemist
(2021)
43,
45
(doi: 10.1042/bio_2021_106)
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, N Nahiyaan, S O'Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell
– Nature Communications
(2021)
12,
143
(doi: 10.1038/s41467-020-20224-x)
Bicyclic 5-5 Systems: Three Heteroatoms 1:2
AG Coyne
(2021)
41
(doi: 10.1016/b978-0-12-409547-2.14914-5)
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Postdoctoral researcher

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01223 336055

Email address

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