Centre for Misfolding Diseases

Dr Anthony Coyne

Chief Part 1B Teaching Laboratory Technician

 

 

Publications

Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells
T Leontidou, Z Yu, J Hess, K Geisler, AG Smith, A Coyne, C Abell
Colloids and surfaces. B, Biointerfaces
(2022)
221
(doi: 10.1016/j.colsurfb.2022.113026)
Development of potent inhibitors by fragment‐linking strategies
EV Bedwell, WJ McCarthy, AG Coyne, C Abell
Chemical Biology & Drug Design
(2022)
100
(doi: 10.1111/cbdd.14120)
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design.
SE Thomas, WJ McCarthy, J El Bakali, KP Brown, SY Kim, M Blaszczyk, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell
Frontiers in Molecular Biosciences
(2022)
9
(doi: 10.3389/fmolb.2022.880432)
Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections.
W Addison, M Frederickson, A Coyne, C Abell
Rsc Medicinal Chemistry
(2022)
13
(doi: 10.1039/d1md00359c)
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients
M Acebrón-García-de-Eulate, J Mayol-Llinàs, MTO Holland, SY Kim, KP Brown, C Marchetti, J Hess, O Di Pietro, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell
Journal of medicinal chemistry
(2022)
65
(doi: 10.1021/acs.jmedchem.1c01684)
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
S Charoensutthivarakul, SE Thomas, A Curran, KP Brown, JM Belardinelli, AJ Whitehouse, M Acebrón-García-de-Eulate, J Sangan, SG Gramani, M Jackson, V Mendes, RA Floto, TL Blundell, AG Coyne, C Abell
ACS Infect Dis
(2022)
8
(doi: 10.1021/acsinfecdis.1c00432)
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
M Frederickson, IR Selvam, D Evangelopoulos, KJ McLean, MM Katariya, RB Tunnicliffe, B Campbell, ME Kavanagh, S Charoensutthivarakul, RT Blankley, CW Levy, LPS de Carvalho, D Leys, AW Munro, AG Coyne, C Abell
European Journal of Medicinal Chemistry
(2022)
230
(doi: 10.1016/j.ejmech.2022.114105)
10.02 Bicyclic 5-5 Systems: Three Heteroatoms 1:2
AG Coyne
(2022)
(doi: 10.1016/b978-0-12-409547-2.14914-5)
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
P Gupta, SE Thomas, SA Zaidan, MA Pasillas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, AG Coyne, WR Jacobs, TL Blundell, S Tiwari, V Mendes
Comput Struct Biotechnol J
(2021)
19
(doi: 10.1016/j.csbj.2021.06.0062001-0370/)
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl- l -cysteine Synthetase (CoaB) Activity
JC Evans, D Murugesan, JM Post, V Mendes, Z Wang, N Nahiyaan, SL Lynch, S Thompson, SR Green, PC Ray, J Hess, C Spry, AG Coyne, C Abell, HIM Boshoff, PG Wyatt, KY Rhee, TL Blundell, CE Barry, V Mizrahi
ACS Infect Dis
(2021)
7
(doi: 10.1021/acsinfecdis.0c00904)

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01223 336363 (shared)

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agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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