Dr Anthony Coyne

Publications

Development of potent inhibitors by fragment-linking strategies.

EV Bedwell, WJ McCarthy, AG Coyne, C Abell

Chemical Biology & Drug Design

(2022)

100

469

(doi: 10.1111/cbdd.14120)

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design

SE Thomas, WJ McCarthy, J El Bakali, KP Brown, SY Kim, M Blaszczyk, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell

Frontiers in molecular biosciences

(2022)

880432

(doi: 10.3389/fmolb.2022.880432)

Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections

W Addison, M Frederickson, AG Coyne, C Abell

RSC Med Chem

(2022)

392

(doi: 10.1039/d1md00359c)

Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients

M Acebrón-García-de-Eulate, J Mayol-Llinàs, MTO Holland, SY Kim, KP Brown, C Marchetti, J Hess, O Di Pietro, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell

Journal of medicinal chemistry

(2022)

2149

(doi: 10.1021/acs.jmedchem.1c01684)

Development of Inhibitors of SAICAR Synthetase (PurC) from <i>Mycobacterium abscessus</i> Using a Fragment-Based Approach.

S Charoensutthivarakul, SE Thomas, A Curran, KP Brown, JM Belardinelli, AJ Whitehouse, M Acebrón-García-de-Eulate, J Sangan, SG Gramani, M Jackson, V Mendes, RA Floto, TL Blundell, AG Coyne, C Abell

ACS Infectious Diseases

(2022)

296

(doi: 10.1021/acsinfecdis.1c00432)

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

M Frederickson, IR Selvam, D Evangelopoulos, KJ McLean, MM Katariya, RB Tunnicliffe, B Campbell, ME Kavanagh, S Charoensutthivarakul, RT Blankley, CW Levy, LPS de Carvalho, D Leys, AW Munro, AG Coyne, C Abell

European Journal of Medicinal Chemistry

(2022)

230

114105

(doi: 10.1016/j.ejmech.2022.114105)

10.02 Bicyclic 5-5 Systems: Three Heteroatoms 1:2

AG Coyne

(2022)

(doi: 10.1016/b978-0-12-409547-2.14914-5)

A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis

P Gupta, SE Thomas, SA Zaidan, MA Pasillas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, AG Coyne, WR Jacobs, TL Blundell, S Tiwari, V Mendes

Computational and structural biotechnology journal

(2021)

3491

(doi: 10.1016/j.csbj.2021.06.006)

Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-L-cysteine Synthetase (CoaB) Activity

JC Evans, D Murugesan, JM Post, V Mendes, Z Wang, N Nahiyaan, SL Lynch, S Thompson, SR Green, PC Ray, J Hess, C Spry, AG Coyne, C Abell, HIM Boshoff, PG Wyatt, KY Rhee, TL Blundell, CE Barry, V Mizrahi

ACS Infect Dis

(2021)

1666

(doi: 10.1021/acsinfecdis.0c00904)

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway ofMycobacterium tuberculosis

P Gupta, S Thomas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, A Coyne, W Jacobs, T Blundell, S Tiwari, V Mendes

(2021)

(doi: 10.1101/2021.03.12.435067)

Dr Anthony Coyne

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