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Centre for Misfolding Diseases

Timothy Welsh

Publications

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
– Proceedings of the National Academy of Sciences
(2022)
119,
e2202222119
(DOI: 10.1073/pnas.2202222119)
Surface interaction patches link non-specific binding and phase separation of antibodies
H Ausserwöger, G Krainer, T Welsh, T Sneideris, M Schneider, G Invernizzi, T Herling, N Lorenzen, T Knowles
(2022)
(DOI: 10.1101/2022.03.07.483238)
Tie-lines reveal interactions driving heteromolecular condensate formation
D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, PS George-Hyslop, T Michaels, T Knowles
(2022)
(DOI: 10.1101/2022.02.22.481401)
Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M Kar, F Dar, T Welsh, L Vogel, R Kühnemuth, A Majumdar, G Krainer, T Franzmann, S Alberti, C Seidel, TPJ Knowles, A Hyman, R Pappu
(2022)
2022.02.03.478969
(DOI: 10.1101/2022.02.03.478969)
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– Nano Letters
(2022)
22,
612
(DOI: 10.1021/acs.nanolett.1c03138)
The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H Zhu, M Narita, J Joseph, G Krainer, W Arter, I Olan, K Saar, N Ermann, J Espinosa, Y Shen, MA Kuri, R Qi, T Welsh, Y Xu, R Collepardo-Guevara, M Narita, T Knowles
(2021)
2021.10.14.464384
(DOI: 10.1101/2021.10.14.464384)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– Nat Commun
(2021)
12,
1085
(DOI: 10.1038/s41467-021-21181-9)
Reentrant Liquid Condensate Phase of Proteins is Stabilized by Hydrophobic and Non-Ionic interactions
G Krainer, TJ Welsh, JA Joseph, P St George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– Biophysical Journal
(2021)
120,
28a
(DOI: 10.1016/j.bpj.2020.11.426)
Direct Digital Sensing of Proteins in Solution through Single-Molecule Optofluidics
G Krainer, KL Saar, WE Arter, TPJ Knowles
– Biophysical Journal
(2021)
120,
114a
(DOI: 10.1016/j.bpj.2020.11.2269)
High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform
W Arter, R Qi, N Erkamp, G Krainer, K Didi, T Welsh, J Acker, J Nixon-Abell, J Nixon-Abell, S Qamar, J Guillén-Boixet, T Franzmann, D Kuster, A Hyman, A Borodavka, P St George-Hyslop, S Alberti, TPJ Knowles
(2020)
2020.06.04.132308
(DOI: 10.1101/2020.06.04.132308)
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Graduate student

Telephone number

01223 748845

Email address

College

St Catharine's College

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    About the University

    Research at Cambridge