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Centre for Misfolding Diseases

Publications

Surface patches induce nonspecific binding and phase separation of antibodies.
H Ausserwöger, G Krainer, TJ Welsh, N Thorsteinson, E de Csilléry, T Sneideris, MM Schneider, T Egebjerg, G Invernizzi, TW Herling, N Lorenzen, TPJ Knowles
– Proceedings of the National Academy of Sciences
(2023)
120,
e2210332120
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform
NA Erkamp, M Oeller, T Sneideris, H Ausserwoger, A Levin, TJ Welsh, R Qi, D Qian, N Lorenzen, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles
– Analytical Chemistry
(2023)
95,
5362
Single-Molecule Sizing through Nanocavity Confinement
RPB Jacquat, G Krainer, QAE Peter, AN Babar, O Vanderpoorten, CK Xu, TJ Welsh, CF Kaminski, UF Keyser, JJ Baumberg, TPJ Knowles
– Nano Lett
(2023)
23,
1629
Direct digital sensing of protein biomarkers in solution.
G Krainer, KL Saar, WE Arter, TJ Welsh, MA Czekalska, RPB Jacquat, Q Peter, WC Traberg, A Pujari, AK Jayaram, P Challa, CG Taylor, L-M van der Linden, T Franzmann, RM Owens, S Alberti, D Klenerman, TPJ Knowles
– Nature communications
(2023)
14,
653
Biophysical characterization of biomolecular condensates through microfluidic technologies
T Welsh
(2023)
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, J Nixon-Abell, S Qamar, J Guillén-Boixet, TM Franzmann, D Kuster, AA Hyman, A Borodavka, PS George-Hyslop, S Alberti, TPJ Knowles
– Nature communications
(2022)
13,
7845
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
– Proc Natl Acad Sci U S A
(2022)
119,
e2202222119
Surface interaction patches link non-specific binding and phase separation of antibodies
H Ausserwöger, G Krainer, T Welsh, T Sneideris, M Schneider, G Invernizzi, T Herling, N Lorenzen, T Knowles
(2022)
Tie-lines reveal interactions driving heteromolecular condensate formation
D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, PS George-Hyslop, T Michaels, T Knowles
(2022)
Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M Kar, F Dar, T Welsh, L Vogel, R Kühnemuth, A Majumdar, G Krainer, T Franzmann, S Alberti, C Seidel, TPJ Knowles, A Hyman, R Pappu
(2022)
2022.02.03.478969
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