Dr Tim Welsh

Publications

Surface patches induce nonspecific binding and phase separation of antibodies

H Ausserwöger, G Krainer, TJ Welsh, N Thorsteinson, E de Csilléry, T Sneideris, MM Schneider, T Egebjerg, G Invernizzi, TW Herling, N Lorenzen, TPJ Knowles

– Proc Natl Acad Sci U S A

(2023)

120,

e2210332120

(doi: 10.1073/pnas.2210332120)

Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform.

NA Erkamp, M Oeller, T Sneideris, H Ausserwoger, A Levin, TJ Welsh, R Qi, D Qian, N Lorenzen, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles

– Analytical Chemistry

(2023)

95,

5362

(doi: 10.1021/acs.analchem.2c05495)

Single-Molecule Sizing through Nanocavity Confinement.

RPB Jacquat, G Krainer, QAE Peter, AN Babar, O Vanderpoorten, CK Xu, TJ Welsh, CF Kaminski, UF Keyser, JJ Baumberg, TPJ Knowles

– Nano letters

(2023)

23,

1629

(doi: 10.1021/acs.nanolett.1c04830)

Direct digital sensing of protein biomarkers in solution.

G Krainer, KL Saar, WE Arter, TJ Welsh, MA Czekalska, RPB Jacquat, Q Peter, WC Traberg, A Pujari, AK Jayaram, P Challa, CG Taylor, L-M van der Linden, T Franzmann, RM Owens, S Alberti, D Klenerman, TPJ Knowles

– Nature Communications

(2023)

14,

653

(doi: 10.1038/s41467-023-35792-x)

Biophysical characterization of biomolecular condensates through microfluidic technologies

T Welsh

(2023)

(doi: 10.17863/CAM.96381)

Biomolecular condensate phase diagrams with a combinatorial microdroplet platform

WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, J Nixon-Abell, S Qamar, J Guillén-Boixet, TM Franzmann, D Kuster, AA Hyman, A Borodavka, PS George-Hyslop, S Alberti, TPJ Knowles

– Nature communications

(2022)

13,

7845

(doi: 10.1038/s41467-022-35265-7)

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.

M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu

– Proc Natl Acad Sci U S A

(2022)

119,

e2202222119

(doi: 10.1073/pnas.2202222119)

Surface interaction patches link non-specific binding and phase separation of antibodies

H Ausserwöger, G Krainer, T Welsh, T Sneideris, M Schneider, G Invernizzi, T Herling, N Lorenzen, T Knowles

(2022)

(doi: 10.1101/2022.03.07.483238)

Tie-lines reveal interactions driving heteromolecular condensate formation

D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, PS George-Hyslop, T Michaels, T Knowles

(2022)

(doi: 10.1101/2022.02.22.481401)

Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

M Kar, F Dar, T Welsh, L Vogel, R Kühnemuth, A Majumdar, G Krainer, T Franzmann, S Alberti, C Seidel, TPJ Knowles, A Hyman, R Pappu

(2022)

2022.02.03.478969

(doi: 10.1101/2022.02.03.478969)

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