Centre for Misfolding Diseases

Dr Tim Welsh

Publications

Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
Nano Lett
(2022)
22
(doi: 10.1021/acs.nanolett.1c03138)
The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, Y Xu, R Collepardo-Guevara, M Narita, TPJ Knowles
(2021)
(doi: 10.1101/2021.10.14.464384)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
Nat Commun
(2021)
12
(doi: 10.1038/s41467-021-21181-9)
Reentrant Liquid Condensate Phase of Proteins is Stabilized by Hydrophobic and Non-Ionic interactions
G Krainer, TJ Welsh, JA Joseph, P St George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
Biophysical Journal
(2021)
120
(doi: 10.1016/j.bpj.2020.11.426)
Direct Digital Sensing of Proteins in Solution through Single-Molecule Optofluidics
G Krainer, KL Saar, WE Arter, TPJ Knowles
Biophysical Journal
(2021)
120
(doi: 10.1016/j.bpj.2020.11.2269)
High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform
WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, J Nixon-Abell, S Qamar, J Guillén-Boixet, TM Franzmann, D Kuster, AA Hyman, A Borodavka, P St George-Hyslop, S Alberti, TPJ Knowles
(2020)
(doi: 10.1101/2020.06.04.132308)
Direct digital sensing of protein biomarkers in solution
G Krainer, KL Saar, WE Arter, TJ Welsh, MA Czekalska, RPB Jacquat, Q Peter, WC Traberg, A Pujari, AK Jayaram, P Challa, CG Taylor, L-M van der Linden, T Franzmann, RM Owens, S Alberti, D Klenerman, TPJ Knowles
BIOPHYSICAL JOURNAL
(2020)
120
(doi: 10.1101/2020.05.24.113498)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, P St George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
BIOPHYSICAL JOURNAL
(2020)
120
(doi: 10.1101/2020.05.04.076299)
Surface electrostatics govern the emulsion stability of biomolecular condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
(2020)
(doi: 10.1101/2020.04.20.047910)
Molecular Forces in the Liquid-Liquid Phase Separation of Biomolecules
TJ Welsh, G Krainer, TP Knowles
Biophysical Journal
(2020)
118
(doi: 10.1016/j.bpj.2019.11.2134)

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01223 336300

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St Catharine's College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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