skip to content
Home

Centre for Misfolding Diseases

Sean Chia

Publications

Trodusquemine enhances A beta(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.
DC Delivoria, S Chia, J Habchi, M Perni, I Matis, N Papaevgeniou, M Reczko, N Chondrogianni, CM Dobson, M Vendruscolo, G Skretas
– Science advances
(2019)
5,
eaax5108
(DOI: 10.1126/sciadv.aax5108)
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
– JoVE
(2019)
2019,
ARTN e60108
(DOI: 10.3791/60108)
Endogenous metabolites rescue a C. elegans model of Alzheimer's disease by triggering a heat shock response
P Joshi, M Perni, R Limbocker, B Mannini, S Casford, S Chia, J Labbadia, C Dobson, M Vendruscolo
– FEBS OPEN BIO
(2019)
9,
225
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's beta-amyloid aggregation
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
– Chem Commun (Camb)
(2019)
55,
1152
(DOI: 10.1039/c8cc09288e)
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Chem Neurosci
(2018)
9,
2959
(DOI: 10.1021/acschemneuro.8b00141)
SAR by kinetics for drug discovery in protein misfolding diseases.
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
10245
(DOI: 10.1073/pnas.1807884115)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
– Nature communications
(2018)
9,
3890
(DOI: 10.1038/s41467-018-06345-4)
Cholesterol catalyses A beta 42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nat Chem
(2018)
10,
673
(DOI: 10.1038/s41557-018-0031-x)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– Annual review of physical chemistry
(2018)
69,
1
(DOI: 10.1146/annurev-physchem-050317-021322)
  • 1 of 2
  • >

Visitor

Telephone number

01223 766544

College

Clare Hall

    Study at Cambridge

    About the University

    Research at Cambridge