Centre for Misfolding Diseases

Sean Chia

Publications

Trodusquemine enhances Aβ 42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
Nature Communications
(2019)
10
(doi: 10.1038/s41467-018-07699-5)
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation
DC Delivoria, S Chia, J Habchi, M Perni, I Matis, N Papaevgeniou, M Reczko, N Chondrogianni, CM Dobson, M Vendruscolo, G Skretas
Science advances
(2019)
5
(doi: 10.1126/sciadv.aax5108)
Characterising Individual Amyloid Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
JoVE
(2019)
2019
(doi: 10.3791/60108)
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation.
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
Chem Commun (Camb)
(2019)
55
(doi: 10.1039/c8cc09288e)
Endogenous metabolites rescue a C. elegans model of Alzheimer's disease by triggering a heat shock response
P Joshi, M Perni, R Limbocker, B Mannini, S Casford, S Chia, J Labbadia, C Dobson, M Vendruscolo
FEBS OPEN BIO
(2019)
9
Stabilization and Characterization of Cytotoxic Aβ
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
ACS Chemical Neuroscience
(2018)
9
(doi: 10.1021/acschemneuro.8b00141)
SAR by kinetics for drug discovery in protein misfolding diseases
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proceedings of the National Academy of Sciences
(2018)
115
(doi: 10.1073/pnas.1807884115)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-06345-4)
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Nat Chem
(2018)
10
(doi: 10.1038/s41557-018-0031-x)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 69
(2018)
69
(doi: 10.1146/annurev-physchem-050317-021322)

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