Sean Chia

Publications

Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease

S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

Biophysical Journal

(2018)

114

225A

(doi: 10.1016/j.bpj.2017.11.1253)

Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates

R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson

Biophysical Journal

(2018)

114

430a

(doi: 10.1016/j.bpj.2017.11.2382)

Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy

FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles

Biophysical Journal

(2018)

114

224A

(doi: 10.1016/j.bpj.2017.11.1246)

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

Proceedings of the National Academy of Sciences

(2017)

114

8005

(doi: 10.1073/pnas.1700239114)

Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species

R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson

Biophysical Journal

(2017)

112

494a

(doi: 10.1016/j.bpj.2016.11.2673)

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

Proceedings of the National Academy of Sciences of the United States of America

(2016)

114

e200

(doi: 10.1073/pnas.1615613114)

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo

ACS Combinatorial Science

(2016)

144

(doi: 10.1021/acscombsci.5b00129)

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo

Sci Adv

(2016)

e1501244

(doi: 10.1126/sciadv.1501244)

Sean Chia

Publications

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