Centre for Misfolding Diseases

Michele Perni

Publications

C. elegans expressing D76N β<sub>2</sub>-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.
G Faravelli, S Raimondi, L Marchese, FA Partridge, C Soria, PP Mangione, D Canetti, M Perni, FA Aprile, I Zorzoli, E Di Schiavi, DA Lomas, V Bellotti, DB Sattelle, S Giorgetti
Sci Rep
(2019)
9
(doi: 10.1038/s41598-019-56498-5)
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
Nature Communications
(2019)
10
(doi: 10.1038/s41467-018-07699-5)
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.
DC Delivoria, S Chia, J Habchi, M Perni, I Matis, N Papaevgeniou, M Reczko, N Chondrogianni, CM Dobson, M Vendruscolo, G Skretas
Sci Adv
(2019)
5
(doi: 10.1126/sciadv.aax5108)
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, Q Peter, G Jiménez-Osés, TPJ Knowles, CM Dobson, F Corzana, M Vendruscolo, GJL Bernardes
ACS Central Science
(2019)
5
(doi: 10.1021/acscentsci.9b00467)
Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo
(2019)
(doi: 10.1101/729392)
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans
RF Laine, T Sinnige, KY Ma, AJ Haack, C Poudel, P Gaida, N Curry, M Perni, EAA Nollen, CM Dobson, M Vendruscolo, GS Kaminski Schierle, CF Kaminski
ACS Chemical Biology
(2019)
14
(doi: 10.1021/acschembio.9b00354)
Probing the Origin of the Toxicity of Oligomeric Aggregates of α‑Synuclein with Antibodies
R Cascella, M Perni, SW Chen, G Fusco, C Cecchi, M Vendruscolo, F Chiti, CM Dobson, A De Simone
ACS Chemical Biology
(2019)
14
(doi: 10.1021/acschembio.9b00312)
Stabilization and Characterization of Cytotoxic Aβ
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
ACS Chemical Neuroscience
(2018)
9
(doi: 10.1021/acschemneuro.8b00141)
Automated behavioral analysis of large c. Elegans populations using a wide field-of-view tracking platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
J Vis Exp
(2018)
2018
(doi: 10.3791/58643)
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
J Neurosci Methods
(2018)
306
(doi: 10.1016/j.jneumeth.2018.02.005)

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