Centre for Misfolding Diseases

Michele Perni

Publications

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
ACS chemical biology
(2018)
13
(doi: 10.1021/acschembio.8b00466)
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, C Cecchi, M Vendruscolo, F Chiti, N Cremades, L Ying, CM Dobson, A De Simone
Science
(2017)
358
(doi: 10.1126/science.aan6160)
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.
M Perni, FA Aprile, S Casford, B Mannini, P Sormanni, CM Dobson, M Vendruscolo
Scientific reports
(2017)
7
(doi: 10.1038/s41598-017-13755-9)
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
Science advances
(2017)
3
(doi: 10.1126/sciadv.1700488)
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
Proc Natl Acad Sci U S A
(2017)
114
(doi: 10.1073/pnas.1610586114)
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proc Natl Acad Sci U S A
(2016)
114
(doi: 10.1073/pnas.1615613114)
Neuroscience: An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer's disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
Science advances
(2016)
2
(doi: 10.1126/sciadv.1501244)

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