Michele Perni

Publications

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson

ACS Chem Biol

(2018)

2308

(doi: 10.1021/acschembio.8b00466)

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, C Cecchi, M Vendruscolo, F Chiti, N Cremades, L Ying, CM Dobson, A De Simone

Science

(2017)

358

1440

(doi: 10.1126/science.aan6160)

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.

M Perni, FA Aprile, S Casford, B Mannini, P Sormanni, CM Dobson, M Vendruscolo

Sci Rep

(2017)

15045

(doi: 10.1038/s41598-017-13755-9)

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.

FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo

Sci Adv

(2017)

e1700488

(doi: 10.1126/sciadv.1700488)

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson

Proceedings of the National Academy of Sciences of the United States of America

(2017)

114

e1009

(doi: 10.1073/pnas.1610586114)

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

Proc Natl Acad Sci U S A

(2016)

114

e200

(doi: 10.1073/pnas.1615613114)

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.

J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo

Science advances

(2016)

e1501244

(doi: 10.1126/sciadv.1501244)

Michele Perni

Publications

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