Gabriella (Gabi) Heller is the Rosalind Franklin Research Fellow at Newnham College. Her research focuses on intrinsically disordered proteins, biomolecules lacking a single, rigid three-dimensional structure that instead exist as a dynamic equilibrium of conformationally distinct states. These proteins are highly prevalent in diseases such as dementia and cancer, yet are often considered therapeutically 'untargetable' as they are unamenable to traditional drug discovery techniques. Gabriella aims to understand whether and how intrinsically disordered proteins can be targeted by small molecule therapeutics using a combination of computational and experimental techniques.
Publications
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
– ACS Chem Biol
(2018)
13,
2308
(DOI: 10.1021/acschembio.8b00466)
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide
– Journal of Molecular Biology
(2017)
429,
2772
(DOI: 10.1016/j.jmb.2017.07.016)
Methods of probing the interactions between small molecules and disordered proteins.
– Cellular and molecular life sciences : CMLS
(2017)
74,
3225
(DOI: 10.1007/s00018-017-2563-4)
Simultaneous quantification of protein order and disorder
– Nature chemical biology
(2017)
13,
339
(DOI: 10.1038/nchembio.2331)
A natural product inhibits the initiation of α-synuclein aggregation & suppresses its toxicity
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
e1009
(DOI: 10.1073/pnas.1610586114)
Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
– Biophysical Journal
(2017)
112,
494A
(DOI: 10.1016/j.bpj.2016.11.2673)
Principles of protein structural ensemble determination
– Curr Opin Struct Biol
(2017)
42,
106
(DOI: 10.1016/j.sbi.2016.12.004)
Targeting disordered proteins with small molecules using entropy.
– Trends in Biochemical Sciences
(2015)
40,
491
(DOI: 10.1016/j.tibs.2015.07.004)
Topological Complexity in Protein Structures
– Computational and Mathematical Biophysics
(2015)
3,
(DOI: 10.1515/mlbmb-2015-0002)
Vocabulary, syntax, and narrative development in typically developing children and children with early unilateral brain injury: early parental talk about the "there-and-then" matters.
– Dev Psychol
(2015)
51,
161
(DOI: 10.1037/a0038476)
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