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Centre for Misfolding Diseases

Dr Georg Krainer

Research Associate

Publications

The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril Ends
M Schneider, S Gautam, T Herling, E Andrzejewska, G Krainer, A Miller, Q Peter, FS Ruggeri, M Vendruscolo, A Bracher, C Dobson, U Hartl, T Knowles
(2020)
2020.11.02.365825
(doi: 10.1101/2020.11.02.365825)
Machine learning models for predicting protein condensate formation from sequence determinants and embeddings
K Saar, A Morgunov, R Qi, W Arter, G Krainer, A Lee, T Knowles
(2020)
2020.10.26.354753
(doi: 10.1101/2020.10.26.354753)
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution
WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles
– Nano Letters
(2020)
20,
8163
(doi: 10.1021/acs.nanolett.0c03260)
SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence
G Krainer, A Hartmann, V Bogatyr, J Nielsen, M Schlierf, DE Otzen
– Chemical science
(2020)
11,
9141
(doi: 10.1039/d0sc02100h)
High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform
W Arter, R Qi, N Erkamp, G Krainer, K Didi, T Welsh, J Acker, J Nixon-Abell, J Nixon-Abell, S Qamar, J Guillén-Boixet, T Franzmann, D Kuster, A Hyman, A Borodavka, P St George-Hyslop, S Alberti, TPJ Knowles
(2020)
2020.06.04.132308
(doi: 10.1101/2020.06.04.132308)
Direct digital sensing of protein biomarkers in solution
G Krainer, K Saar, W Arter, T Welsh, M Czekalska, RPB Jacquat, Q Peter, W Traberg, W Traberg, A Pujari, A Jayaram, P Challa, C Taylor, L-M van der Linden, T Franzmann, R Owens, S Alberti, D Klenerman, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
120,
2020.05.24.113498
(doi: 10.1101/2020.05.24.113498)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
G Krainer, TJ Welsh, JA Joseph, P St George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
120,
2020.05.04.076299
(doi: 10.1101/2020.05.04.076299)
Surface electrostatics govern the emulsion stability of biomolecular condensates
T Welsh, G Krainer, J Espinosa, J Joseph, A Sridhar, M Jahnel, W Arter, K Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
(2020)
2020.04.20.047910
(doi: 10.1101/2020.04.20.047910)
Microfluidic approaches for the analysis of protein–protein interactions in solution
WE Arter, A Levin, G Krainer, TPJ Knowles
– Biophysical Reviews
(2020)
12,
575
(doi: 10.1007/s12551-020-00679-4)
Rapid Fractionation and Characterisation of Alpha-Synuclein Oligomers in Solution
W Arter, C Xu, M Castellana-Cruz, T Herling, G Krainer, K Saar, J Kumita, C Dobson, T Knowles
(2020)
2020.03.10.985804
(doi: 10.1101/2020.03.10.985804)
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