Centre for Misfolding Diseases

Dr Georg Krainer

Research Associate

Publications

The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H Zhu, M Narita, J Joseph, G Krainer, W Arter, I Olan, K Saar, N Ermann, J Espinosa, Y Shen, MA Kuri, R Qi, T Welsh, Y Xu, R Collepardo-Guevara, M Narita, T Knowles
(2021)
(doi: 10.1101/2021.10.14.464384)
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends
MM Schneider, S Gautam, TW Herling, E Andrzejewska, G Krainer, AM Miller, VA Trinkaus, QAE Peter, FS Ruggeri, M Vendruscolo, A Bracher, CM Dobson, FU Hartl, TPJ Knowles
Nat Commun
(2021)
12
(doi: 10.1038/s41467-021-25966-w)
Can single-component protein condensates form multiphase architectures?
A Garaizar, J Espinosa, J Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
(2021)
(doi: 10.1101/2021.10.09.463670)
Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses
F Geiger, J Acker, G Papa, X Wang, WE Arter, KL Saar, N Erkamp, R Qi, J Bravo, S Strauss, G Krainer, OR Burrone, R Jungmann, TPJ Knowles, H Engelke, A Borodavka
EMBO Journal
(2021)
40
(doi: 10.15252/embj.2021107711)
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation
J Wen, L Hong, G Krainer, Q-Q Yao, TPJ Knowles, S Wu, S Perrett
J Am Chem Soc
(2021)
143
(doi: 10.1021/jacs.1c03078)
Liquid-Liquid Phase-Separated Systems from Reversible Gel-Sol Transition of Protein Microgels.
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
Advanced Materials
(2021)
33
(doi: 10.1002/adma.202008670)
Heat treatment of thioredoxin fusions increases the purity of α‐helical transmembrane protein constructs
M Schenkel, A Treff, CM Deber, G Krainer, M Schlierf
Protein science : a publication of the Protein Society
(2021)
30
(doi: 10.1002/pro.4150)
Uncertainty in protein-ligand binding constants: asymmetric confidence intervals versus standard errors.
V Paketurytė, V Petrauskas, A Zubrienė, O Abian, M Bastos, W-Y Chen, MJ Moreno, G Krainer, V Linkuvienė, A Sedivy, A Velazquez-Campoy, MA Williams, D Matulis
Eur Biophys J
(2021)
50
(doi: 10.1007/s00249-021-01518-4)
Learning the molecular grammar of protein condensates from sequence determinants and embeddings.
KL Saar, AS Morgunov, R Qi, WE Arter, G Krainer, AA Lee, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2021)
118
(doi: 10.1073/pnas.2019053118)
Chaperones Skp and SurA dynamically expand unfolded outer membrane protein X and synergistically disassemble oligomeric aggregates
N Chamachi, A Hartmann, MQ Ma, G Krainer, M Schlierf
(2021)
(doi: 10.1101/2021.02.23.432414)

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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