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Centre for Misfolding Diseases

Dr Georg Krainer

Research Associate

Publications

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides.
T Sneideris, NA Erkamp, H Ausserwöger, KL Saar, TJ Welsh, D Qian, K Katsuya-Gaviria, MLLY Johncock, G Krainer, A Borodavka, TPJ Knowles
– Nature communications
(2023)
14,
7170
(doi: 10.1038/s41467-023-42374-4)
An automated single-molecule FRET platform for high-content, multiwell plate screening of biomolecular conformations and dynamics.
A Hartmann, K Sreenivasa, M Schenkel, N Chamachi, P Schake, G Krainer, M Schlierf
– Nature Communications
(2023)
14,
6511
(doi: 10.1038/s41467-023-42232-3)
Single-molecule digital sizing of proteins in solution
G Krainer, RPB Jacquat, M Schneider, T Welsh, J Fan, Q Peter, E Andrzejewska, G Šneiderienė, M Czekalska, H Ausserwoeger, L Chai, W Arter, K Saar, T Herling, T Franzmann, V Kosmoliaptsis, S Alberti, F-U Hartl, S Lee, TPJ Knowles
(2023)
(doi: 10.1101/2023.07.12.548675)
Quantifying collective interactions in biomolecular phase separation
H Ausserwöger, D Qian, G Krainer, E de Csilléry, T Welsh, T Sneideris, T Franzmann, S Qamar, N Erkamp, J Nixon-Abell, M Kar, PS George-Hyslop, A Hyman, S Alberti, R Pappu, T Knowles
(2023)
(doi: 10.1101/2023.05.31.543137)
α-Synuclein oligomers form by secondary nucleation
C Xu, G Meisl, E Andrzejewska, G Krainer, A Dear, MC Cruz, S Turi, R Jacquat, W Arter, M Vendruscolo, S Linse, TPJ Knowles
(2023)
(doi: 10.1101/2023.05.28.542651)
Surface patches induce nonspecific binding and phase separation of antibodies
H Ausserwöger, G Krainer, TJ Welsh, N Thorsteinson, E de Csilléry, T Sneideris, MM Schneider, T Egebjerg, G Invernizzi, TW Herling, N Lorenzen, TPJ Knowles
– Proc Natl Acad Sci U S A
(2023)
120,
e2210332120
(doi: 10.1073/pnas.2210332120)
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins.
G Agam, C Gebhardt, M Popara, R Mächtel, J Folz, B Ambrose, N Chamachi, SY Chung, TD Craggs, M de Boer, D Grohmann, T Ha, A Hartmann, J Hendrix, V Hirschfeld, CG Hübner, T Hugel, D Kammerer, H-S Kang, AN Kapanidis, G Krainer, K Kramm, EA Lemke, E Lerner, E Margeat, K Martens, J Michaelis, J Mitra, GG Moya Muñoz, RB Quast, NC Robb, M Sattler, M Schlierf, J Schneider, T Schröder, A Sefer, PS Tan, J Thurn, P Tinnefeld, J van Noort, S Weiss, N Wendler, N Zijlstra, A Barth, CAM Seidel, DC Lamb, T Cordes
– Nat Methods
(2023)
20,
523
(doi: 10.1038/s41592-023-01807-0)
α-synuclein oligomers displace monomeric α-synuclein from lipid membranes
G Šneiderienė, M Czekalska, C Xu, A Jayaram, G Krainer, W Arter, Q Peter, M Castellana-Cruz, K Saar, A Levin, T Mueller, S Fiedler, S Devenish, H Fiegler, J Kumita, T Knowles
(2023)
(doi: 10.1101/2023.03.21.533646)
Modulating Nucleic Acid Phase Transitions as a Mechanism of Action for Cell-Penetrating Antimicrobial Peptides
T Sneideris, N Erkamp, H Ausserwöger, K Saar, T Welsh, D Qian, M Johncock, G Krainer, A Borodavka, T Knowles
(2023)
(doi: 10.1101/2023.03.11.532143)
Farewell to single-well: An automated single-molecule FRET platform for high-content, multiwell plate screening of biomolecular conformations and dynamics
A Hartmann, K Sreenivasa, M Schenkel, N Chamachi, P Schake, G Krainer, M Schlierf
(2023)
(doi: 10.1101/2023.02.28.530427)
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    Research at Cambridge