Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.


In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.


For a complete list of publications please see below:

Publications

Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
Nature Communications
(2017)
8
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
D Klenerman, M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
BMC Biol
(2017)
15
Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation‐Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6
A Chiki, SM DeGuire, FS Ruggeri, D Sanfelice, A Ansaloni, Z-M Wang, U Cendrowska, R Burai, S Vieweg, A Pastore, G Dietler, HA Lashuel
Angew Chem Int Ed Engl
(2017)
56
Nanoplasmonic mid-infrared biosensor for
D Etezadi, JB Warner Iv, FS Ruggeri, G Dietler, HA Lashuel, H Altug
Light, science & applications
(2017)
6
Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson
Biophysical Journal
(2017)
112
Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy
FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46
Mid-infrared plasmonic nanoantennas for protein structure detection
D Etezadi, JB Warner, FS Ruggeri, G Dietler, HA Lashuel, H Altug
2017 CONFERENCE ON LASERS AND ELECTRO-OPTICS EUROPE & EUROPEAN QUANTUM ELECTRONICS CONFERENCE (CLEO/EUROPE-EQEC)
(2017)
Part F81-EQEC 2017
Micro- and nanoscale hierarchical structure of core-shell protein microgels.
LR Volpatti, U Shimanovich, FS Ruggeri, S Bolisetty, T Müller, TO Mason, TCT Michaels, R Mezzenga, G Dietler, TPJ Knowles
J Mater Chem B
(2016)
4
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates
D Galante, FS Ruggeri, G Dietler, F Pellistri, E Gatta, A Corsaro, T Florio, A Perico, C D'Arrigo
International Journal of Biochemistry and Cell Biology
(2016)
79
Nanoscale studies link amyloid maturity with polyglutamine diseases onset.
FS Ruggeri, S Vieweg, U Cendrowska, G Longo, A Chiki, HA Lashuel, G Dietler
Scientific Reports
(2016)
6

Postdoctoral researcher

Telephone number

01223 763845 (shared), 01223 763842