Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.


In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.


For a complete list of publications please see below:

Publications

AFM-based single molecule techniques: Unraveling the amyloid Pathogenic Species
FS Ruggeri, J Habchi, A Cerreta, G Dietler
Current Pharmaceutical Design
(2016)
22
Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.
FS Ruggeri, G Longo, S Faggiano, E Lipiec, A Pastore, G Dietler
Nature Communications
(2015)
6
Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization
FS Ruggeri, J Adamcik, JS Jeong, HA Lashuel, R Mezzenga, G Dietler
Angewandte Chemie International Edition
(2015)
54
Detecting nanoscale vibrations as signature of life.
S Kasas, FS Ruggeri, C Benadiba, C Maillard, P Stupar, H Tournu, G Dietler, G Longo
Proc Natl Acad Sci U S A
(2014)
112
Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor α-derived peptide.
FS Ruggeri, C Byrne, L Khemtemourian, G Ducouret, G Dietler, Y Jacquot
J Pept Sci
(2014)
21
Corrigendum: One‐Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington’s Disease
A Ansaloni, ZM Wang, JS Jeong, FS Ruggeri, G Dietler, HA Lashuel
Angewandte Chemie International Edition
(2014)
53
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
O Khalaf, B Fauvet, A Oueslati, I Dikiy, A-L Mahul-Mellier, FS Ruggeri, MK Mbefo, F Vercruysse, G Dietler, S-J Lee, D Eliezer, HA Lashuel
The Journal of biological chemistry
(2014)
289
One-pot semisynthesis of exon 1 of the Huntingtin protein: New tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease
A Ansaloni, Z-M Wang, JS Jeong, FS Ruggeri, G Dietler, HA Lashuel
Angew Chem Int Ed Engl
(2014)
53
One‐Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington’s Disease
A Ansaloni, Z Wang, JS Jeong, FS Ruggeri, G Dietler, HA Lashuel
Angewandte Chemie
(2014)
126
Nanoscale spatially resolved infrared spectra from single microdroplets.
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
Lab Chip
(2014)
14

Postdoctoral researcher

Telephone number

01223 763845 (shared), 01223 763842