Research Associate

I currently work at the Centre for Misfolding Diseases at the University of Cambridge. The focus of my original research programme is to develop and apply new Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.


In my research, I continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.


For a complete list of publications please see below:

Publications

AFM-based single molecule techniques: Unraveling the amyloid Pathogenic Species
FS Ruggeri, J Habchi, A Cerreta, G Dietler
Curr Pharm Des
(2016)
22
Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.
FS Ruggeri, G Longo, S Faggiano, E Lipiec, A Pastore, G Dietler
Nature Communications
(2015)
6
Influence of the β‐Sheet Content on the Mechanical Properties of Aggregates during Amyloid Fibrillization
FS Ruggeri, J Adamcik, JS Jeong, HA Lashuel, R Mezzenga, G Dietler
Angew Chem Int Ed Engl
(2015)
54
Detecting nanoscale vibrations as signature of life
S Kasas, FS Ruggeri, C Benadiba, C Maillard, P Stupar, H Tournu, G Dietler, G Longo
Proceedings of the National Academy of Sciences of the United States of America
(2014)
112
Concentration‐dependent and surface‐assisted self‐assembly properties of a bioactive estrogen receptor α‐derived peptide
FS Ruggeri, C Byrne, L Khemtemourian, G Ducouret, G Dietler, Y Jacquot
J Pept Sci
(2014)
21
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
O Khalaf, B Fauvet, A Oueslati, I Dikiy, A-L Mahul-Mellier, FS Ruggeri, MK Mbefo, F Vercruysse, G Dietler, S-J Lee, D Eliezer, HA Lashuel
J Biol Chem
(2014)
289
One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington's Disease
A Ansaloni, Z-M Wang, JS Jeong, FS Ruggeri, G Dietler, HA Lashuel
Angewandte Chemie International Edition
(2014)
53
One‐Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington’s Disease
A Ansaloni, Z Wang, JS Jeong, FS Ruggeri, G Dietler, HA Lashuel
Angewandte Chemie
(2014)
126
Nanoscale spatially resolved infrared spectra from single microdroplets.
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
Lab on a chip
(2014)
14
Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.
J Adamcik, C Lara, I Usov, JS Jeong, FS Ruggeri, G Dietler, HA Lashuel, IW Hamley, R Mezzenga
Nanoscale
(2012)
4

Postdoctoral researcher

Telephone number

01223 763845 (shared), 01223 763842