Centre for Misfolding Diseases

Francesco Aprile

Senior Research Fellow

Publications

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates.
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Chem Commun (Camb)
(2015)
51
(doi: 10.1039/c5cc03689e)
The CamSol method of rational design of protein mutants with enhanced solubility.
P Sormanni, FA Aprile, M Vendruscolo
Journal of molecular biology
(2014)
427
(doi: 10.1016/j.jmb.2014.09.026)
NMR characterization of the conformational fluctuations of the human lymphocyte function‐associated antigen‐1 I‐domain
HTA Leung, P Kukic, C Camilloni, F Bemporad, A De Simone, FA Aprile, JR Kumita, M Vendruscolo
Protein Sci
(2014)
23
(doi: 10.1002/pro.2538)
Determination of Primary Nucleation Mechanisms of α-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
BIOPHYSICAL JOURNAL
(2014)
106
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
Journal of Molecular Biology
(2013)
425
(doi: 10.1016/j.jmb.2013.01.040)
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, CV Robinson, X Salvatella, CM Dobson, N Cremades
PLoS ONE
(2013)
8
(doi: 10.1371/journal.pone.0067961)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
Journal of molecular biology
(2013)
425
(doi: 10.1016/j.jmb.2013.01.040)
The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.
G Invernizzi, FA Aprile, A Natalello, A Ghisleni, A Penco, A Relini, SM Doglia, P Tortora, ME Regonesi
PLoS ONE
(2012)
7
(doi: 10.1371/journal.pone.0051890)
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
Cell
(2012)
149
(doi: 10.1016/j.cell.2012.03.037)
Insights into the molecular mechanisms of Hsp70-mediated inhibition of amyloid formation
FA Aprile, A Dhulesia, F Stengel, T Eliseo, C Roodvelt, B Bolognesi, P Tortora, X Salvatella, N Cremades, CM Dobson
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40

Research Staff Scientist

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01223 763845 (shared), 01223 763842
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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