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Centre for Misfolding Diseases

Francesco Aprile

Senior Research Fellow

Publications

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical communications (Cambridge, England)
(2015)
51,
14425
(doi: 10.1039/c5cc03689e)
Rapid sizing of proteins in complex solutions
P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S49
(link to publication)
The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility
P Sormanni, FA Aprile, M Vendruscolo
– Journal of Molecular Biology
(2014)
427,
478
(doi: 10.1016/j.jmb.2014.09.026)
NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain
HTA Leung, P Kukic, C Camilloni, F Bemporad, A De Simone, FA Aprile, JR Kumita, M Vendruscolo
– Protein Science
(2014)
23,
1596
(doi: 10.1002/pro.2538)
Determination of Primary Nucleation Mechanisms of α-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2014)
106,
267A
(link to publication)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
– Journal of Molecular Biology
(2013)
425,
2397
(doi: 10.1016/j.jmb.2013.01.040)
Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, CV Robinson, X Salvatella, CM Dobson, N Cremades
– PloS one
(2013)
8,
e67961
(doi: 10.1371/journal.pone.0067961)
Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
– J Mol Biol
(2013)
425,
2397
(doi: 10.1016/j.jmb.2013.01.040)
The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli
G Invernizzi, FA Aprile, A Natalello, A Ghisleni, A Penco, A Relini, SM Doglia, P Tortora, ME Regonesi
– PLoS ONE
(2012)
7,
e51890
(doi: 10.1371/journal.pone.0051890)
Direct observation of the interconversion of normal and toxic forms of α-synuclein.
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
– Cell
(2012)
149,
1048
(doi: 10.1016/j.cell.2012.03.037)
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01223 763842

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