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Centre for Misfolding Diseases

Francesco Aprile

Senior Research Fellow

Publications

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.
G Faravelli, S Raimondi, L Marchese, FA Partridge, C Soria, PP Mangione, D Canetti, M Perni, FA Aprile, I Zorzoli, E Di Schiavi, DA Lomas, V Bellotti, DB Sattelle, S Giorgetti
– Scientific Reports
(2019)
9,
19960
(doi: 10.1038/s41598-019-56498-5)
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, Q Peter, G Jiménez-Osés, TPJ Knowles, CM Dobson, F Corzana, M Vendruscolo, GJL Bernardes
– ACS central science
(2019)
5,
1417
(doi: 10.1021/acscentsci.9b00467)
Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo
(2019)
729392
(doi: 10.1101/729392)
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
– Acta Neuropathologica Communications
(2019)
7,
120
(doi: 10.1186/s40478-019-0777-4)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nat Commun
(2019)
10,
1541
(doi: 10.1038/s41467-019-09477-3)
Probing Specificity in Disordered Protein Interactions with Small Molecules using Integrative Methods
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, M Vendruscolo
– Biophysical Journal
(2019)
116,
180A
(doi: 10.1016/j.bpj.2018.11.998)
Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, CM Dobson, M Vendruscolo
– Biophysical Journal
(2019)
116,
28A
(doi: 10.1016/j.bpj.2018.11.196)
Automated behavioral analysis of large c. Elegans populations using a wide field-of-view tracking platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
– Journal of visualized experiments : JoVE
(2018)
2018,
ARTN e58643
(doi: 10.3791/58643)
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
S Giorgetti, C Greco, P Tortora, FA Aprile
– International journal of molecular sciences
(2018)
19,
E2677
(doi: 10.3390/ijms19092677)
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
S Giorgetti, C Greco, P Tortora, FA Aprile
(2018)
(doi: 10.20944/preprints201808.0155.v1)
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01223 763845 (shared)

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