Centre for Misfolding Diseases

Dr Benedetta Mannini

Publications

Chaperones as suppressors of protein misfolded oligomer toxicity
B Mannini, F Chiti
Front Mol Neurosci
(2017)
10
(doi: 10.3389/FNMOL.2017.00098)
Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson
Biophysical Journal
(2017)
112
(doi: 10.1016/j.bpj.2016.11.2673)
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proceedings of the National Academy of Sciences
(2016)
114
(doi: 10.1073/pnas.1615613114)
Bis(indolyl)phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme.
H Ramshini, B Mannini, K Khodayari, A Ebrahim-Habibi, AS Moghaddasi, R Tayebee, F Chiti
Eur J Med Chem
(2016)
124
(doi: 10.1016/j.ejmech.2016.08.056)
Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations
S Cappelli, A Penco, B Mannini, R Cascella, MR Wilson, H Ecroyd, X Li, JN Buxbaum, CM Dobson, C Cecchi, A Relini, F Chiti
Biol Chem
(2016)
397
(doi: 10.1515/hsz-2015-0250)
SERS detection of amyloid oligomers on metallorganic-decorated plasmonic beads
L Guerrini, R Arenal, B Mannini, F Chiti, R Pini, P Matteini, RA Alvarez-Puebla
ACS Applied Materials & Interfaces
(2015)
7
(doi: 10.1021/acsami.5b01056)
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity.
B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, M Ramazzotti, CM Dobson, C Cecchi, F Chiti
ACS Chemical Biology
(2014)
9
(doi: 10.1021/cb500505m)
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro
R Cascella, S Conti, B Mannini, X Li, JN Buxbaum, B Tiribilli, F Chiti, C Cecchi
Biochimica et Biophysica Acta
(2013)
1832
(doi: 10.1016/j.bbadis.2013.09.011)
Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N
F Tatini, AM Pugliese, C Traini, S Niccoli, G Maraula, T Ed Dami, B Mannini, T Scartabelli, F Pedata, F Casamenti, F Chiti
Neurobiology of Aging
(2013)
34
(doi: 10.1016/j.neurobiolaging.2013.03.020)
Salt Anions Promote the Conversion of HypF-N into Amyloid-Like Oligomers and Modulate the Structure of the Oligomers and the Monomeric Precursor State
S Campioni, B Mannini, JP López-Alonso, IN Shalova, A Penco, E Mulvihill, DV Laurents, A Relini, F Chiti
Journal of Molecular Biology
(2012)
424
(doi: 10.1016/j.jmb.2012.09.023)

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Yusuf Hamied Department of Chemistry
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CB2 1EW
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