Dr Benedetta Mannini

Publications

Proteome-wide observation of the phenomenon of life on the edge of solubility

G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, FU Hartl, M Vendruscolo

Proceedings of the National Academy of Sciences of the United States of America

(2019)

117

1015

(doi: 10.1073/pnas.1910444117)

Trodusquemine enhances Aβ₄₂ aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson

Nature Communications

(2019)

225

(doi: 10.1038/s41467-018-07699-5)

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo

(2019)

729392

(doi: 10.1101/729392)

Differential interactome and innate immune response activation of two structurally distinct misfolded protein oligomers.

B Mannini, G Vecchi, A Labrador-Garrido, B Fabre, G Fani, JM Franco, K Lilley, D Pozo, M Vendruscolo, F Chiti, CM Dobson, C Roodveldt

ACS Chemical Neuroscience

(2019)

3464

(doi: 10.1021/acschemneuro.9b00088)

Stabilization and Characterization of Cytotoxic Aβ₄₀ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo

ACS Chem Neurosci

(2018)

2959

(doi: 10.1021/acschemneuro.8b00141)

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson

ACS Chemical Biology

(2018)

2308

(doi: 10.1021/acschembio.8b00466)

Toxic HypF-N Oligomers Selectively Bind the Plasma Membrane to Impair Cell Adhesion Capability

R Oropesa-Nuñez, S Keshavan, S Dante, A Diaspro, B Mannini, C Capitini, C Cecchi, M Stefani, F Chiti, C Canale

Biophys J

(2018)

114

1357

(doi: 10.1016/j.bpj.2018.02.003)

Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease

S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

Biophysical Journal

(2018)

114

225A

(doi: 10.1016/j.bpj.2017.11.1253)

Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates

R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson

Biophysical Journal

(2018)

114

430a

(doi: 10.1016/j.bpj.2017.11.2382)

Delivery of Native Proteins into C-elegans Using a Transduction Protocol Based on Lipid Vesicles

M Perni, FA Aprile, S Casford, B Mannini, P Sormanni, CM Dobson, M Vendruscolo

Scientific reports

(2017)

15045

(doi: 10.1038/s41598-017-13755-9)

Dr Benedetta Mannini

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