Publications

Substrate Fragmentation for the Design of M.tuberculosis CYP121 Inhibitors
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
ChemMedChem
(2016)
11
Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis
HJ Davis, ME Kavanagh, T Balan, C Abell, AG Coyne
Bioorg Med Chem Lett
(2016)
26
Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.
ME Kavanagh, AG Coyne, KJ McLean, GG James, CW Levy, LB Marino, LPS de Carvalho, DSH Chan, SA Hudson, S Surade, D Leys, AW Munro, C Abell
Journal of medicinal chemistry
(2016)
59
CHAPTER 8 Fragment-Based Discovery of Antibacterials
C Spry, AG Coyne
(2015)
ChemInform Abstract: Regioselective Conversion of Arenes to N‐Aryl‐1,2,3‐triazoles Using C—H Borylation.
R Srinivasan, AG Coyne, C Abell
ChemInform
(2015)
46
Understanding “On-Water” Catalysis of Organic Reactions. Effects of H+ and Li+ Ions in the Aqueous Phase and Nonreacting Competitor H-Bond Acceptors in the Organic Phase: On H2O versus on D2O for Huisgen Cycloadditions
RN Butler, AG Coyne
J Org Chem
(2015)
80
Natural product-inspired fragment-based drug discovery: Development of M. tuberculosis CYP121 inhibitors
M Kavanagh, J Gray, A Coyne, H Davis, K McLean, A Munro, C Abell
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2015)
250
Fragment-based drug discovery of potent and selective CYP121 inhibitors for tuberculosis
M Kavanagh, A Coyne, G James, K McLean, S Hudson, LP de Carvalho, A Munro, C Abell
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2015)
250
Small-Molecule Inhibitors That Target Protein-Protein Interactions in the RAD51 Family of Recombinases
DE Scott, AG Coyne, A Venkitaraman, TL Blundell, C Abell, M Hyvönen
ChemMedChem
(2014)
10
Regioselective conversion of arenes to N-aryl-1,2,3-triazoles Using C-H Borylation
R Srinivasan, AG Coyne, C Abell
Chemistry (Weinheim an der Bergstrasse, Germany)
(2014)
20

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