Dr Anthony Coyne

Publications

Water and organic synthesis: a focus on the in-water and on-water border. Reversal of the in-water Breslow hydrophobic enhancement of the normal endo-effect on crossing to on-water conditions for Huisgen cycloadditions with increasingly insoluble organic liquid and solid 2π-dipolarophiles.

RN Butler, AG Coyne, WJ Cunningham, EM Moloney

Journal of Organic Chemistry

(2013)

3276

(doi: 10.1021/jo400055g)

Fragment-based approaches in drug discovery and chemical biology

DE Scott, AG Coyne, SA Hudson, C Abell

Biochemistry

(2012)

4990

(doi: 10.1021/bi3005126)

ChemInform Abstract: Asymmetric Electrocyclic Reactions

S Thompson, AG Coyne, PC Knipe, MD Smith

ChemInform

(2011)

(doi: 10.1002/chin.201149243)

Fragment based approach to targeting the Rad51:BRCA2 protein-protein interaction

AG Coyne, DE Scott, C Abell, M Marsh, M Hyvonen, TL Blundell, A Venkitaraman

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2011)

242

Asymmetric electrocyclic reactions.

S Thompson, AG Coyne, PC Knipe, MD Smith

Chem Soc Rev

(2011)

4217

(doi: 10.1039/c1cs15022g)

Trapping of palindromic ligands within native transthyretin prevents amyloid formation.

SE Kolstoe, PP Mangione, V Bellotti, GW Taylor, GA Tennent, S Deroo, AJ Morrison, AJA Cobb, A Coyne, MG McCammon, TD Warner, J Mitchell, R Gill, MD Smith, SV Ley, CV Robinson, SP Wood, MB Pepys

Proceedings of the National Academy of Sciences of the United States of America

(2010)

107

20483

(doi: 10.1073/pnas.1008255107)

Water: nature's reaction enforcer--comparative effects for organic synthesis "in-water" and "on-water".

RN Butler, AG Coyne

Chemical Reviews

(2010)

110

6302

(doi: 10.1021/cr100162c)

ChemInform Abstract: Regioselectivity and endo/exo Selectivity in the Cycloadditions of the Phthalazinium Dicyanomethanide 1,3‐Dipole with Unsymmetrical Alkene and Alkyne Dipolarophiles. Unexpected Reversals of Regiochemistry: A Combined Experimental and DFT Theoretical Study.

RN Butler, AG Coyne, P McArdle, D Cunningham, LA Burke

ChemInform

(2010)

(doi: 10.1002/chin.200143032)

ChemInform Abstract: Ligand Design for Intermolecular Asymmetric Mizoroki—Heck Reactions

AG Coyne, MO Fitzpatrick, PJ Guiry

ChemInform

(2010)

(doi: 10.1002/chin.201020231)

Novel palindromic ligands cementing the native quaternary structure of transthyretin

PP Mangione, V Bellotti, S Deroo, GW Taylor, MG McCammon, CV Robinson, GA Tennent, MD Smith, AJ Morrison, AJA Cobb, A Coyne, SV Ley, SW Wood, MB Pepys

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

(2010)

Dr Anthony Coyne

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