Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

Fragment-based approaches in drug discovery and chemical biology
DE Scott, AG Coyne, SA Hudson, C Abell
Biochemistry
(2012)
51
(doi: 10.1021/bi3005126)
ChemInform Abstract: Asymmetric Electrocyclic Reactions
S Thompson, AG Coyne, PC Knipe, MD Smith
ChemInform
(2011)
42
(doi: 10.1002/chin.201149243)
Fragment based approach to targeting the Rad51:BRCA2 protein-protein interaction
AG Coyne, DE Scott, C Abell, M Marsh, M Hyvonen, TL Blundell, A Venkitaraman
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2011)
242
Asymmetric electrocyclic reactions
S Thompson, AG Coyne, PC Knipe, MD Smith
Chemical Society Reviews
(2011)
40
(doi: 10.1039/c1cs15022g)
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
SE Kolstoe, PP Mangione, V Bellotti, GW Taylor, GA Tennent, S Deroo, AJ Morrison, AJA Cobb, A Coyne, MG McCammon, TD Warner, J Mitchell, R Gill, MD Smith, SV Ley, CV Robinson, SP Wood, MB Pepys
Proceedings of the National Academy of Sciences
(2010)
107
(doi: 10.1073/pnas.1008255107)
Water: Nature's Reaction Enforcer-Comparative Effects for Organic Synthesis "In-Water" and "On-Water"
RN Butler, AG Coyne
Chem Rev
(2010)
110
(doi: 10.1021/cr100162c)
ChemInform Abstract: Regioselectivity and endo/exo Selectivity in the Cycloadditions of the Phthalazinium Dicyanomethanide 1,3‐Dipole with Unsymmetrical Alkene and Alkyne Dipolarophiles. Unexpected Reversals of Regiochemistry: A Combined Experimental and DFT Theoretical Study.
RN Butler, AG Coyne, P McArdle, D Cunningham, LA Burke
ChemInform
(2010)
32
(doi: 10.1002/chin.200143032)
ChemInform Abstract: Ligand Design for Intermolecular Asymmetric Mizoroki—Heck Reactions
AG Coyne, MO Fitzpatrick, PJ Guiry
ChemInform
(2010)
41
(doi: 10.1002/chin.201020231)
Novel palindromic ligands cementing the native quaternary structure of transthyretin
PP Mangione, V Bellotti, S Deroo, GW Taylor, MG McCammon, CV Robinson, GA Tennent, MD Smith, AJ Morrison, AJA Cobb, A Coyne, SV Ley, SW Wood, MB Pepys
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17
Targeting transthyretin - X-ray crystallography and rational drug design
S Kolstoe, AJ Morrison, AJA Cobb, A Coyne, R Gill, MD Smith, SV Ley, SP Wood, MB Pepys
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17

Postdoctoral researcher

Email address

agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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