Centre for Misfolding Diseases

Dr Anthony Coyne

Chief Part 1B Teaching Laboratory Technician

 

 

Publications

Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
Journal of medicinal chemistry
(2019)
62
(doi: 10.1021/acs.jmedchem.9b00809)
Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, D Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, A Coyne
(2019)
(doi: 10.26434/chemrxiv.8131847.v1)
Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
RC Panicker, AG Coyne, R Srinivasan
Current Medicinal Chemistry
(2019)
26
(doi: 10.2174/0929867324666170727120315)
Structure-guided Fragment-based Drug Discovery at the Synchrotron: Screening Binding Sites and Correlations with Hotspot Mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, C Radoux, C Abell, AG Coyne, RA Floto, F von Delft, TL Blundell
Philos Trans A Math Phys Eng Sci
(2019)
377
(doi: 10.1098/rsta.2018.0422)
meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation
X Li, X Deng, AG Coyne, R Srinivasan
Chemistry – A European Journal
(2019)
25
(doi: 10.1002/chem.201901633)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
SE Thomas, AJ Whitehouse, K Brown, JM Belardinelli, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
(2019)
(doi: 10.1101/564013)
A fragment-based approach to targeting inosine-5´- monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, TL Blundell, DB Ascher, C Abell
J Med Chem
(2018)
61
(doi: 10.1021/acs.jmedchem.7b01622)
Mass spectrometry for fragment screening
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
Essays in biochemistry
(2017)
61
(doi: 10.1042/EBC20170071)
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
DSH Chan, M Kavanagh, K McLean, A Munro, D Matak-Vinkovic, A Coyne, C Abell
Analytical chemistry
(2017)
89
(doi: 10.1021/acs.analchem.7b02329)
Fragment screening against the EthR-DNA interaction by native mass spectrometry
DSH Chan, V Mendes, S Thomas, B McConnell, D Matak-Vinkovic, A Coyne, T Blundell, C Abell
Angew Chem Int Ed Engl
(2017)
56
(doi: 10.1002/anie.201702888)

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01223 336363 (shared)

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agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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