Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

Development of inhibitors against mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
J Med Chem
(2019)
62
(doi: 10.1021/acs.jmedchem.9b00809)
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, C Radoux, C Abell, AG Coyne, RA Floto, F von Delft, TL Blundell
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
(2019)
377
(doi: 10.1098/rsta.2018.0422)
Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
A Whitehouse, S Thomas, K Brown, A Fanourakis, D Chan, D Libardo, V Mendes, H Boshoff, A Floto, C Abell, T Blundell, A Coyne
(2019)
(doi: 10.26434/chemrxiv.8131847.v1)
meta‐Nitration of Arenes Bearing ortho/para Directing Group(s) Using C−H Borylation
X Li, X Deng, AG Coyne, R Srinivasan
Chemistry
(2019)
25
(doi: 10.1002/chem.201901633)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
S Thomas, A Whitehouse, K Brown, J Belardinelli, R Lahiri, D Libardo, P Gupta, S Malhotra, H Boshoff, M Jackson, C Abell, A Coyne, T Blundell, R Andres Floto, V Mendes
(2019)
(doi: 10.1101/564013)
Allosteric targeting of aurora a kinase using small molecules: A step forward towards next generation medicines?
RC Panicker, AG Coyne, R Srinivasan
Curr Med Chem
(2019)
26
(doi: 10.2174/0929867324666170727120315)
A fragment-based approach to targeting inosine-5´- monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, TL Blundell, DB Ascher, C Abell
Journal of Medicinal Chemistry
(2018)
61
(doi: 10.1021/acs.jmedchem.7b01622)
Mass spectrometry for fragment screening
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
Essays Biochem
(2017)
61
(doi: 10.1042/ebc20170071)
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
DSH Chan, M Kavanagh, K McLean, A Munro, D Matak-Vinkovic, A Coyne, C Abell
Anal Chem
(2017)
89
(doi: 10.1021/acs.analchem.7b02329)
Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.
DSH Chan, V Mendes, S Thomas, B McConnell, D Matak-Vinkovic, A Coyne, T Blundell, C Abell
Angewandte Chemie International Edition
(2017)
56
(doi: 10.1002/anie.201702888)

Postdoctoral researcher

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01223 336055

Email address

agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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