Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

The Application of Fragment-based Approaches to the Discovery of Drugs for Neglected Tropical Diseases
C Spry, AG Coyne
(2019)
(doi: 10.1201/9781351011655-2)
Allosteric targeting of aurora a kinase using small molecules: A step forward towards next generation medicines?
RC Panicker, AG Coyne, R Srinivasan
Curr Med Chem
(2019)
26
(doi: 10.2174/0929867324666170727120315)
Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches.
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
J Med Chem
(2019)
62
(doi: 10.1021/acs.jmedchem.9b00809)
Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, D Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, A Coyne
(2019)
(doi: 10.26434/chemrxiv.8131847.v1)
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, C Radoux, C Abell, AG Coyne, RA Floto, F von Delft, TL Blundell
Philos Trans A Math Phys Eng Sci
(2019)
377
(doi: 10.1098/rsta.2018.0422)
Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, D Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, A Coyne
(2019)
(doi: 10.26434/chemrxiv.8131847)
meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation.
X Li, X Deng, AG Coyne, R Srinivasan
Chemistry (Weinheim an der Bergstrasse, Germany)
(2019)
25
(doi: 10.1002/chem.201901633)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
SE Thomas, AJ Whitehouse, K Brown, JM Belardinelli, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
(2019)
(doi: 10.1101/564013)
Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, TL Blundell, DB Ascher, C Abell
J Med Chem
(2018)
61
(doi: 10.1021/acs.jmedchem.7b01622)
Mass spectrometry for fragment screening.
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
Essays in Biochemistry
(2017)
61
(doi: 10.1042/ebc20170071)

Postdoctoral researcher

Email address

agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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