Francesco Aprile

Senior Research Fellow

Publications

C. elegans expressing D76N β<sub>2</sub>-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.

G Faravelli, S Raimondi, L Marchese, FA Partridge, C Soria, PP Mangione, D Canetti, M Perni, FA Aprile, I Zorzoli, E Di Schiavi, DA Lomas, V Bellotti, DB Sattelle, S Giorgetti

Scientific reports

(2019)

19960

(doi: 10.1038/s41598-019-56498-5)

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, Q Peter, G Jiménez-Osés, TPJ Knowles, CM Dobson, F Corzana, M Vendruscolo, GJL Bernardes

ACS Central Science

(2019)

1417

(doi: 10.1021/acscentsci.9b00467)

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo

(2019)

729392

(doi: 10.1101/729392)

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman

Acta Neuropathol Commun

(2019)

120

(doi: 10.1186/s40478-019-0777-4)

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman

Nature Communications

(2019)

1541

(doi: 10.1038/s41467-019-09477-3)