Centre for Misfolding Diseases

Dr Paolo Arosio

Marie Curie Research Fellow

I received my master degree in chemical engineering in 2007 at the Politecnico di Milano (Italy), and my PhD degree at the Institute for Chemical and Bioengineering at ETH Zurich (CH) in 2011. My PhD studies in the physical chemistry and biophysics research areas were concerned with the colloidal stability of polymers, proteins and peptides. Currently, I am a Marie Curie postdoctoral Fellow in the group of Dr. Knowles at the Department of Chemistry of the University of Cambridge.

My research interests consist in applying concepts from physical chemistry and chemical engineering to address complex problems in biology and biotechnology of both fundamental and pratical relevance, focusing in particular on the reaction mechanisms of biomolecules. My research strategy involves the combination of experimental and theoretical activities to improve the mechanistic understanding of the process.

Major research topics include the aggregation mechanisms of amyloidogenic proteins in misfolding disorders and of therapeutic proteins in the biopharmaceutical industry. 

Publications

http://scholar.google.com/citations?user=AYM_whEAAAAJ&hl=it

Publications

Dynamics of protein aggregation and oligomer formation governed by secondary nucleation
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
The Journal of chemical physics
(2015)
143
(doi: 10.1063/1.4927655)
Preventing peptide and protein misbehavior.
P Arosio, G Meisl, M Andreasen, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2015)
112
(doi: 10.1073/pnas.1505170112)
A multiscale view of therapeutic protein aggregation: a colloid science perspective.
L Nicoud, M Owczarz, P Arosio, M Morbidelli
Biotechnology Journal
(2015)
10
(doi: 10.1002/biot.201400858)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
Nature structural & molecular biology
(2015)
22
(doi: 10.1038/nsmb.2971)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstal, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
Nature Structural & Molecular Biology
(2015)
22
(doi: 10.1038/nsmb.2971)
A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution
TW Herling, P Arosio, T Müller, S Linse, TPJ Knowles
Physical Chemistry Chemical Physics
(2015)
17
(doi: 10.1039/c5cp00746a)
On the lag phase in amyloid fibril formation.
P Arosio, TPJ Knowles, S Linse
Phys Chem Chem Phys
(2015)
17
(doi: 10.1039/c4cp05563b)
Effect of polyol sugars on the stabilization of monoclonal antibodies.
L Nicoud, N Cohrs, P Arosio, E Norrant, M Morbidelli
Biophysical Chemistry
(2014)
197
(doi: 10.1016/j.bpc.2014.12.003)
Role of Cosolutes in the Aggregation Kinetics of Monoclonal Antibodies
L Nicoud, M Sozo, P Arosio, A Yates, E Norrant, M Morbidelli
The journal of physical chemistry. B
(2014)
118
(doi: 10.1021/jp508000w)
Sol-gel transition of charged fibrils composed of a model amphiphilic peptide.
M Owczarz, S Bolisetty, R Mezzenga, P Arosio
Journal of Colloid and Interface Science
(2014)
437
(doi: 10.1016/j.jcis.2014.09.022)

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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