Dr Paolo Arosio

Marie Curie Research Fellow

I received my master degree in chemical engineering in 2007 at the Politecnico di Milano (Italy), and my PhD degree at the Institute for Chemical and Bioengineering at ETH Zurich (CH) in 2011. My PhD studies in the physical chemistry and biophysics research areas were concerned with the colloidal stability of polymers, proteins and peptides. Currently, I am a Marie Curie postdoctoral Fellow in the group of Dr. Knowles at the Department of Chemistry of the University of Cambridge.

My research interests consist in applying concepts from physical chemistry and chemical engineering to address complex problems in biology and biotechnology of both fundamental and pratical relevance, focusing in particular on the reaction mechanisms of biomolecules. My research strategy involves the combination of experimental and theoretical activities to improve the mechanistic understanding of the process.

Major research topics include the aggregation mechanisms of amyloidogenic proteins in misfolding disorders and of therapeutic proteins in the biopharmaceutical industry.

Publications

http://scholar.google.com/citations?user=AYM_whEAAAAJ&hl=it

Publications

Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation

C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson

Journal of Biological Chemistry

(2014)

289

31066

(doi: 10.1074/jbc.M114.595124)

Kinetic analysis of the multistep aggregation mechanism of monoclonal antibodies

L Nicoud, P Arosio, M Sozo, A Yates, E Norrant, M Morbidelli

Journal of Physical Chemistry B

(2014)

118

10595

(doi: 10.1021/jp505295j)

Sulfate anion delays the self-assembly of human insulin by modifying the aggregation pathway.

M Owczarz, P Arosio

Biophys J

(2014)

107

197

(doi: 10.1016/j.bpj.2014.05.030)

Density-gradient-free microfluidic centrifugation for analytical and preparative separation of nanoparticles

P Arosio, T Müller, L Mahadevan, TPJ Knowles

Nano letters

(2014)

2365

(doi: 10.1021/nl404771g)

Chemical kinetics for drug discovery to combat protein aggregation diseases

P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

Trends in Pharmacological Sciences

(2014)

127

(doi: 10.1016/j.tips.2013.12.005)

The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.

N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen

Journal of the American Chemical Society

(2014)

136

3859

(doi: 10.1021/ja411577t)

Chemical kinetics for drug discovery to combat protein aggregation diseases.

P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

Trends in pharmacological sciences

(2014)

127

(doi: 10.1016/j.tips.2013.12.005)

Chemical kinetics for drug discovery to combat protein aggregation diseases

P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

Trends in Pharmacological Sciences

(2014)

127

Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics

P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

Biophysical Journal

(2014)

106

682A

(doi: 10.1016/j.bpj.2013.11.3776)

Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay

P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse

Journal of the American Chemical Society

(2013)

136

219

(doi: 10.1021/ja408765u)

Dr Paolo Arosio

Marie Curie Research Fellow

Publications

Postdoctoral researcher

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge