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Centre for Misfolding Diseases

Dr Sarah Meehan

Royal Society Dororthy Hodgkin Research Fellow

Publications

Metastability of native proteins and the phenomenon of amyloid formation.
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson
– J Am Chem Soc
(2011)
133,
14160
(doi: 10.1021/ja2017703)
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action
B Mannini, S Campioni, M Boninsegna, E Palagano, R Cascella, M Zampagni, A Penco, M Wilson, S Meehan, C Roodveldt, A Relini, C Cecchi, F Chiti
– FEBS JOURNAL
(2011)
278,
117
(link to publication)
Iron promotes the toxicity of amyloid β peptide by impeding its ordered aggregation
B Liu, A Moloney, S Meehan, K Morris, SE Thomas, LC Serpell, R Hider, SJ Marciniak, DA Lomas, DC Crowther
– Journal of Biological Chemistry
(2010)
286,
4248
(doi: 10.1074/jbc.m110.158980)
The interaction of unfolding α-lactalbumin and malate dehydrogenase with the molecular chaperone αB-crystallin: a light and X-ray scattering investigation
JW Regini, H Ecroyd, S Meehan, K Bremmell, MJ Clarke, D Lammie, T Wess, JA Carver
– Molecular vision
(2010)
16,
2446
(link to publication)
Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody
EJ De Genst, T Guilliams, J Wellens, EM O'Day, CA Waudby, S Meehan, M Dumoulin, S-TD Hsu, N Cremades, KHG Verschueren, E Pardon, L Wyns, J Steyaert, J Christodoulou, CM Dobson
– Journal of Molecular Biology
(2010)
402,
326
(doi: 10.1016/j.jmb.2010.07.001)
The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation
CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ME Welland, J Christodoulou, CM Dobson, S Meehan
– Biophys J
(2010)
98,
843
(doi: 10.1016/j.bpj.2009.10.056)
Imaging amyloid fibrils within cells using a Se-labelling strategy.
AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ME Welland, CM Dobson
– Journal of Molecular Biology
(2009)
392,
868
(doi: 10.1016/j.jmb.2009.07.061)
Protein nanofibres of defined morphology prepared from mixtures of crude crystallins
M Garvey, SL Gras, S Meehan, SJ Meade, JA Carver, JA Gerrard
– International Journal of Nanotechnology
(2009)
6,
258
(doi: 10.1504/ijnt.2009.022918)
α2-Macroglobulin and Haptoglobin Suppress Amyloid Formation by Interacting with Prefibrillar Protein Species*
JJ Yerbury, JR Kumita, S Meehan, CM Dobson, MR Wilson
– The Journal of biological chemistry
(2008)
284,
4246
(doi: 10.1074/jbc.m807242200)
Role of intermolecular forces in defining material properties of protein nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, CM Dobson, ME Welland
– Science (New York, N.Y.)
(2007)
318,
1900
(doi: 10.1126/science.1150057)
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