Centre for Misfolding Diseases

Dr Sarah Meehan

Royal Society Dororthy Hodgkin Research Fellow

Publications

Site-Directed Mutations in the C-Terminal Extension of Human αB-Crystallin Affect Chaperone Function and Block Amyloid Fibril Formation
TM Treweek, H Ecroyd, DM Williams, S Meehan, JA Carver, MJ Walker
PloS one
(2007)
2
(doi: 10.1371/journal.pone.0001046)
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human αA-, αβ- and R120G αB-Crystallins
S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, TM Treweek, H Ecroyd, GG Tartaglia, M Vendruscolo, CE Macphee, CM Dobson, JA Carver
Journal of molecular biology
(2007)
372
(doi: 10.1016/j.jmb.2007.06.060)
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass.
TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ME Welland
Proceedings of the National Academy of Sciences
(2007)
104
(doi: 10.1073/pnas.0610659104)
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures
JJ Yerbury, S Poon, S Meehan, B Thompson, JR Kumita, CM Dobson, MR Wilson
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
(2007)
21
(doi: 10.1096/fj.06-7986com)
Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity.
H Ecroyd, S Meehan, J Horwitz, JA Aquilina, JLP Benesch, CV Robinson, CE Macphee, JA Carver
Biochemical Journal
(2006)
401
(doi: 10.1042/bj20060981)
Amyloid fibril formation by bovine milk κ-casein and its inhibition by the molecular chaperones αs- and β-casein
DC Thorn, S Meehan, M Sunde, A Rekas, SL Gras, CE MacPhee, CM Dobson, MR Wilson, JA Carver
Biochemistry
(2005)
44
(doi: 10.1021/bi051352r)
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation
S Meehan, Y Berry, B Luisi, CM Dobson, JA Carver, CE MacPhee
The Journal of biological chemistry
(2003)
279
(doi: 10.1074/jbc.m308203200)

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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