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Centre for Misfolding Diseases

Dr Sarah (Gomersall) Shammas

Senior Research Associate

Publications

Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies.
SL Shammas, MD Crabtree, L Dahal, BIM Wicky, J Clarke
– The Journal of biological chemistry
(2016)
291,
6689
(doi: 10.1074/jbc.R115.692715)
Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors
S Milles, D Mercadante, IV Aramburu, MR Jensen, N Banterle, C Koehler, S Tyagi, J Clarke, SL Shammas, M Blackledge, F Gräter, EA Lemke
– Cell
(2015)
163,
734
(doi: 10.1016/j.cell.2015.09.047)
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
– Nature communications
(2015)
6,
7025
(doi: 10.1038/ncomms8025)
IDPs that Fold Upon Binding: What is the Role of the Partner Protein?
SL Shammas, J Rogers, M Crabtree, J Clarke
– Biophysical Journal
(2015)
108,
228a
(doi: 10.1016/j.bpj.2014.11.1257)
Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein
JM Rogers, V Oleinikovas, SL Shammas, CT Wong, D De Sancho, CM Baker, J Clarke
– Proc Natl Acad Sci U S A
(2014)
111,
15420
(doi: 10.1073/pnas.1409122111)
Allostery within a transcription coactivator is predominantly mediated through dissociation rate constants.
SL Shammas, AJ Travis, J Clarke
– Proceedings of the National Academy of Sciences
(2014)
111,
12055
(doi: 10.1073/pnas.1405815111)
Mechanism of assembly of the non-covalent spectrin tetramerization domain from intrinsically disordered partners
SA Hill, LG Kwa, SL Shammas, JC Lee, J Clarke
– Journal of Molecular Biology
(2014)
426,
21
(doi: 10.1016/j.jmb.2013.08.027)
Speed Dating with KIX: A Single Domain that has Many Partners
SL Shammas, J Clarke
– Biophysical Journal
(2014)
106,
426A
(doi: 10.1016/j.bpj.2013.11.2401)
Tau-Hsp70 Interaction at the Single-Molecule Level
F Kundel, M Kjaergaard, SL Shammas, SE Jackson, D Klenerman
– Biophysical Journal
(2014)
106,
59a
(doi: 10.1016/j.bpj.2013.11.406)
Mechanism of Assembly of the Non-Covalent Spectrin Tetramerization Domain from Intrinsically Disordered Partners
SA Hill, LG Kwa, SL Shammas, JC Lee, J Clarke
– J Mol Biol
(2013)
426,
21
(doi: 10.1016/j.jmb.2013.08.027)
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