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Centre for Misfolding Diseases

Dr Sarah (Gomersall) Shammas

Senior Research Associate

Publications

Remarkably fast coupled folding and binding of the intrinsically disordered transactivation domain of cMyb to CBP KIX.
SL Shammas, AJ Travis, J Clarke
– The Journal of Physical Chemistry B
(2013)
117,
13346
(doi: 10.1021/jp404267e)
Single Molecule Fluorescence Studies of Amyloid Beta 1-42 Aggregation
JA Flint, P Narayan, MH Horrocks, SL Shammas, M Kjaergaard, D Klenerman
– Biophysical Journal
(2013)
104,
359a
(doi: 10.1016/j.bpj.2012.11.1997)
Folding Upon Binding - Not a Simple Protein Folding Problem
J Clarke, JM Rogers, SA Hill, SL Shammas, D Gruszka, A Steward, JC Lee, JR Potts
– Biophysical Journal
(2013)
104,
189A
(doi: 10.1016/j.bpj.2012.11.1069)
Slow, reversible, coupled folding and binding of the spectrin tetramerization domain.
SL Shammas, JM Rogers, SA Hill, J Clarke
– Biophysical Journal
(2012)
103,
2203
(doi: 10.1016/j.bpj.2012.10.012)
Protein folding: Adding a nucleus to guide helix docking reduces landscape roughness
BG Wensley, LG Kwa, SL Shammas, JM Rogers, J Clarke
– Journal of Molecular Biology
(2012)
423,
273
(doi: 10.1016/j.jmb.2012.08.003)
Protein folding: adding a nucleus to guide helix docking reduces landscape roughness.
BG Wensley, LG Kwa, SL Shammas, JM Rogers, J Clarke
– J Mol Biol
(2012)
423,
273
(doi: 10.1016/j.jmb.2012.08.003)
Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains
BG Wensley, LG Kwa, SL Shammas, JM Rogers, S Browning, Z Yang, J Clarke
– Proc Natl Acad Sci U S A
(2012)
109,
17795
(doi: 10.1073/pnas.1201793109)
Single Molecule Fluorescence Studies of Amyloid-Beta 1-42 Aggregation
JA Flint, P Narayan, MH Horrocks, SL Shammas, D Klenerman
– Biophysical Journal
(2012)
102,
443a
(doi: 10.1016/j.bpj.2011.11.2426)
Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation
SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ME Welland, JA Carver, CM Dobson, S Meehan
– Biophysical Journal
(2011)
101,
1681
(doi: 10.1016/j.bpj.2011.07.056)
Metastability of native proteins and the phenomenon of amyloid formation
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson
– Journal of the American Chemical Society
(2011)
133,
14160
(doi: 10.1021/ja2017703)
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