Ryan Limbocker

Publications

Trodusquemine enhances Aβ₄₂ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson

Nature communications

(2019)

225

(doi: 10.1038/s41467-018-07699-5)

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo

(2019)

729392

(doi: 10.1101/729392)

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles

J Neurosci Methods

(2018)

306

(doi: 10.1016/j.jneumeth.2018.02.005)

O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES

FA Aprile, P Sormanni, M Perni, P Arosio, R Limbocker, S Chhangur, B Mannini, S Linse, T Knowles, CM Dobson, M Vendruscolo

Alzheimer's & Dementia

(2018)

p611

(doi: 10.1016/j.jalz.2018.06.2646)

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson

ACS Chemical Biology

(2018)

2308

(doi: 10.1021/acschembio.8b00466)

Regional differences in dopamine release in the R6/2 mouse caudate putamen.

SV Kaplan, RA Limbocker, B Levant, MA Johnson

Electroanalysis

(2018)

1066

(doi: 10.1002/elan.201700827)

Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease

S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

Biophysical Journal

(2018)

114

225A

(doi: 10.1016/j.bpj.2017.11.1253)

Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates

R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson

Biophysical Journal

(2018)

114

430A

(doi: 10.1016/j.bpj.2017.11.2382)

A natural product inhibits the initiation of α-synuclein aggregation & suppresses its toxicity

M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson

Proceedings of the National Academy of Sciences of the United States of America

(2017)

114

E1009

(doi: 10.1073/pnas.1610586114)

Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species

R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson

Biophysical Journal

(2017)

112

494a

(doi: 10.1016/j.bpj.2016.11.2673)

Ryan Limbocker

Publications

Postgraduate student

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge