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Centre for Misfolding Diseases

Rob Horne

Publications

Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
– Nature chemical biology
(2024)
(doi: 10.1038/s41589-024-01580-x)
Sequence-Based Drug Design Using Transformers
M Vendruscolo, S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan
(2024)
(doi: 10.21203/rs.3.rs-3682847/v1)
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity.
RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, RC Gregory, A Possenti, S Chia, M Vendruscolo
– J Chem Inf Model
(2024)
64,
590
(doi: 10.1021/acs.jcim.3c01777)
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors
R Chandra, RI Horne, M Vendruscolo
– Journal of Chemical Theory and Computation
(2023)
20,
469
(doi: 10.1021/acs.jctc.3c01224)
Sequence-based drug design using transformers
S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan, M Vendruscolo
(2023)
(doi: 10.1101/2023.11.27.568880)
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
– J Am Chem Soc
(2023)
145,
25776
(doi: 10.1021/jacs.3c09335)
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
A Dear, X Teng, S Ball, J Lewin, R Horne, D Clow, N Harper, K Yahya, TCT Michaels, S Linse, T Knowles, X Yang, S Brewerton, J Thomson, J Habchi, G Meisl
(2023)
(doi: 10.1101/2023.10.20.563279)
Drug discovery for misfolding diseases using structure-based iterative learning
R Horne
(2023)
(doi: 10.17863/CAM.106944)
Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation
R Staats, ZF Brotzakis, S Chia, RI Horne, M Vendruscolo
– Front Mol Biosci
(2023)
10,
1155753
(doi: 10.3389/fmolb.2023.1155753)
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts
RI Horne, MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, G Meisl, M Vendruscolo
– ACS Chem Neurosci
(2023)
14,
3125
(doi: 10.1021/acschemneuro.3c00282)
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01223 763284

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Pembroke College

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