Rob Horne

Publications

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo

– Molecular Pharmaceutics

(2022)

A Machine Learning Approach to Identify Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation

R Horne, A Possenti, S Chia, F Brotzakis, R Staats, M Nowinska, M Vendruscolo

(2022)

Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates

S Chia, ZF Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo

(2021)

A Machine Learning Approach to Identify Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation

RI Horne, A Possenti, S Chia, ZF Brotzakis, R Staats, M Nowinska, M Vendruscolo

(2021)

2021.11.10.468009

Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

FS Ruggeri, J Habchi, S Chia, RI Horne, M Vendruscolo, TPJ Knowles

– Nature Communications

(2021)

12,

688

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo

– Communications Chemistry

(2020)

191