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Centre for Misfolding Diseases

Publications

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
– Molecular Pharmaceutics
(2022)
A Machine Learning Approach to Identify Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation
R Horne, A Possenti, S Chia, F Brotzakis, R Staats, M Nowinska, M Vendruscolo
(2022)
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
S Chia, ZF Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
(2021)
A Machine Learning Approach to Identify Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation
RI Horne, A Possenti, S Chia, ZF Brotzakis, R Staats, M Nowinska, M Vendruscolo
(2021)
2021.11.10.468009
Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers
FS Ruggeri, J Habchi, S Chia, RI Horne, M Vendruscolo, TPJ Knowles
– Nature Communications
(2021)
12,
688
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Communications Chemistry
(2020)
3,
191

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