Rob Horne

Publications

Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.

RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo

Nature chemical biology

(2024)

634

(doi: 10.1038/s41589-024-01580-x)

Sequence-Based Drug Design Using Transformers

M Vendruscolo, S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan

(2024)

(doi: 10.21203/rs.3.rs-3682847/v1)

Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity.

RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, RC Gregory, A Possenti, S Chia, M Vendruscolo

Journal of Chemical Information and Modeling

(2024)

590

(doi: 10.1021/acs.jcim.3c01777)

Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors

R Chandra, RI Horne, M Vendruscolo

J Chem Theory Comput

(2023)

469

(doi: 10.1021/acs.jctc.3c01224)

Sequence-based drug design using transformers

S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan, M Vendruscolo

(2023)

(doi: 10.1101/2023.11.27.568880)

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores

SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo

J Am Chem Soc

(2023)

145

25776

(doi: 10.1021/jacs.3c09335)

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed

A Dear, X Teng, S Ball, J Lewin, R Horne, D Clow, N Harper, K Yahya, TCT Michaels, S Linse, T Knowles, X Yang, S Brewerton, J Thomson, J Habchi, G Meisl

(2023)

(doi: 10.1101/2023.10.20.563279)

Drug discovery for misfolding diseases using structure-based iterative learning

R Horne

(2023)

(doi: 10.17863/CAM.106944)

Optimization of a small molecule inhibitor of secondary nucleation in a-synuclein aggregation

R Staats, ZF Brotzakis, S Chia, RI Horne, M Vendruscolo

Front Mol Biosci

(2023)

1155753

(doi: 10.3389/fmolb.2023.1155753)

Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α‑Synuclein at Physiological pH with Sodium Salts

RI Horne, MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, G Meisl, M Vendruscolo

ACS Chemical Neuroscience

(2023)

3125

(doi: 10.1021/acschemneuro.3c00282)

Rob Horne

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