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Centre for Misfolding Diseases

Dr Pavan Kumar Challa

Research Associate

My goal is to build a single cell proteomics platform for molecular diagnostics.

Publications

Gradient-free determination of isoelectric points of proteins on chip.
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, T Knowles
– Physical chemistry chemical physics : PCCP
(2017)
19,
23060
(doi: 10.1039/c7cp01503h)
Correction for: A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E1009-E1017) DOI: 10.1073/pnas.1610586114)
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proc Natl Acad Sci U S A
(2017)
114,
e2543
(doi: 10.1073/pnas.1701964114)
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
(doi: 10.1073/pnas.1610586114)
Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2017)
112,
494A
(doi: 10.1016/j.bpj.2016.11.2673)
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, X Yang, S Linse, TPJ Knowles
– Lab on a Chip
(2017)
18,
162
(doi: 10.1039/c7lc00797c)
Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning
PK Challa, T Kartanas, J Charmet, TPJ Knowles
– Biomicrofluidics
(2017)
11,
014113
(doi: 10.1063/1.4976690)
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proc Natl Acad Sci U S A
(2016)
114,
e200
(doi: 10.1073/pnas.1615613114)
Spontaneously modulated chiral nematic structures of flexible bent-core liquid crystal dimers
SM Salili, RR Ribeiro de Almeida, PK Challa, SN Sprunt, JT Gleeson, A Jákli
– Liquid Crystals
(2016)
44,
160
(doi: 10.1080/02678292.2016.1225836)
Fluctuation Modes of a Twist-Bend Nematic Liquid Crystal
Z Parsouzi, SM Shamid, V Borshch, PK Challa, AR Baldwin, MG Tamba, C Welch, GH Mehl, JT Gleeson, A Jakli, OD Lavrentovich, DW Allender, JV Selinger, S Sprunt
– Physical Review X
(2016)
6,
021041
(doi: 10.1103/physrevx.6.021041)
Peculiarities of the magneto-optical response in dispersions of anisometric pigment nano-particles (vol 6, pg 80666, 2016)
A Eremin, Y Geng, R Stannarius, T Ostapenko, PK Challa, JT Gleeson, A Jakli, S Klein
– RSC Advances
(2016)
6,
87103
(doi: 10.1039/c6ra90089e)
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Postdoctoral researcher

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    Research at Cambridge