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Centre for Misfolding Diseases

Dr Pavan Kumar Challa

Research Associate

My goal is to build a single cell proteomics platform for molecular diagnostics.

Publications

Gradient-free determination of isoelectric points of proteins on chip
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, T Knowles
– Physical Chemistry Chemical Physics
(2017)
19,
23060
(doi: 10.1039/c7cp01503h)
Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences
(2017)
114,
E2543
(doi: 10.1073/pnas.1701964114)
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proc Natl Acad Sci U S A
(2017)
114,
e1009
(doi: 10.1073/pnas.1610586114)
Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2017)
112,
494A
(doi: 10.1016/j.bpj.2016.11.2673)
Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning
PK Challa, T Kartanas, J Charmet, TPJ Knowles
– Biomicrofluidics
(2017)
11,
014113
(doi: 10.1063/1.4976690)
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, X Yang, S Linse, TPJ Knowles
– Lab Chip
(2017)
18,
162
(doi: 10.1039/c7lc00797c)
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2016)
114,
E200
(doi: 10.1073/pnas.1615613114)
Spontaneously modulated chiral nematic structures of flexible bent-core liquid crystal dimers
SM Salili, RR Ribeiro de Almeida, PK Challa, SN Sprunt, JT Gleeson, A Jákli
– Liquid Crystals
(2016)
44,
1
(doi: 10.1080/02678292.2016.1225836)
Peculiarities of the magneto-optical response in dispersions of anisometric pigment nano-particles
A Eremin, Y Geng, R Stannarius, T Ostapenko, PK Challa, JT Gleeson, A Jákli, S Klein
– RSC Advances
(2016)
6,
80666
(doi: 10.1039/c6ra12020b)
Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
– 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
(2016)
1079
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    Research at Cambridge