Centre for Misfolding Diseases

Dr Pavan Kumar Challa

Research Associate

My goal is to build a single cell proteomics platform for molecular diagnostics.

Publications

Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.
C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet
Lab Chip
(2018)
19
(doi: 10.1039/c8lc00757h)
Collective dynamics in dispersions of anisometric pigment particles
K May, R Stannarius, K Kang, PK Challa, S Sprunt, A Jákli, S Klein, A Eremin
Journal of Molecular Liquids
(2018)
267
(doi: 10.1016/j.molliq.2018.01.172)
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal of Neuroscience Methods
(2018)
306
(doi: 10.1016/j.jneumeth.2018.02.005)
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
ACS Chemical Biology
(2018)
13
(doi: 10.1021/acschembio.8b00466)
Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
Analytical chemistry
(2018)
90
(doi: 10.1021/acs.analchem.8b01205)
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
Anal Chem
(2018)
90
(doi: 10.1021/acs.analchem.7b04523)
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1253)
2-Photon Lithography for Nanofluidic Lab-on-Chip Devices
O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, CF Kaminski
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3716)
Observation of molecular self-assembly events in massively parallel microdroplet arrays.
Z Toprakcioglu, PK Challa, A Levin, TPJ Knowles
Lab on a Chip
(2018)
18
(doi: 10.1039/c8lc00862k)
Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems
T Kartanas, V Ostanin, PK Challa, R Daly, J Charmet, TPJ Knowles
Analytical Chemistry
(2017)
89
(doi: 10.1021/acs.analchem.7b01174)

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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