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Centre for Misfolding Diseases

Dr Nunilo Cremades

Research Fellow

Publications

Insights into the molecular mechanisms of Hsp70-mediated inhibition of amyloid formation
FA Aprile, A Dhulesia, F Stengel, T Eliseo, C Roodvelt, B Bolognesi, P Tortora, X Salvatella, N Cremades, CM Dobson
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40,
87
(link to publication)
Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein
N Cremades, SIA Cohen, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, TPJ Knowles, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40,
215
(link to publication)
Population of nonnative states of lysozyme variants drives amyloid fibril formation
AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ME Welland, TPJ Knowles, X Salvatella, CM Dobson
– J Am Chem Soc
(2011)
133,
7737
(doi: 10.1021/ja109620d)
Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution
A Dhulesia, N Cremades, JR Kumita, S-TD Hsu, MF Mossuto, M Dumoulin, D Nietlispach, M Akke, X Salvatella, CM Dobson
– J Am Chem Soc
(2010)
132,
15580
(doi: 10.1021/ja103524m)
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody
EJ De Genst, T Guilliams, J Wellens, EM O'Day, CA Waudby, S Meehan, M Dumoulin, S-TD Hsu, N Cremades, KHG Verschueren, E Pardon, L Wyns, J Steyaert, J Christodoulou, CM Dobson
– J Mol Biol
(2010)
402,
326
(doi: 10.1016/j.jmb.2010.07.001)
Influence of Nanobodies on the aggregation properties of Alpha-synuclein
T Guilliams, E De Genst, E Pardon, N Cremades, J Steyaert, L Wyns, C Dobson
– FEBS JOURNAL
(2010)
277,
84
(link to publication)
Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents against Helicobacter pylori Infection
N Cremades, A Velázquez-Campoy, M Martínez-Júlvez, JL Neira, I Pérez-Dorado, J Hermoso, P Jiménez, A Lanas, PS Hoffman, J Sancho
– ACS chemical biology
(2009)
4,
928
(doi: 10.1021/cb900166q)
On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of alpha-Synuclein with Congo Red and Lacmoid
C Lendel, CW Bertoncini, N Cremades, CA Waudby, M Vendruscolo, CM Dobson, D Schenk, J Christodoulou, G Toth
– Biochemistry
(2009)
48,
8322
(doi: 10.1021/bi901285x)
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria
AL Pey, M Ying, N Cremades, A Velazquez-Campoy, T Scherer, B Thöny, J Sancho, A Martinez
– J Clin Invest
(2008)
118,
2858
(doi: 10.1172/jci34355)
Molten Globule and Native State Ensemble of Helicobacter pylori Flavodoxin: Can Crowding, Osmolytes or Cofactors Stabilize the Native Conformation Relative to the Molten Globule?
N Cremades, J Sancho
– Biophysical Journal
(2008)
95,
1913
(doi: 10.1529/biophysj.108.130153)
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