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Centre for Misfolding Diseases

Dr Nunilo Cremades

Research Fellow

Publications

Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– PROTEIN SCIENCE
(2015)
24,
136
(link to publication)
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
– PLoS ONE
(2014)
9,
e87133
(doi: 10.1371/journal.pone.0087133)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
– Journal of Molecular Biology
(2013)
425,
2397
(doi: 10.1016/j.jmb.2013.01.040)
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, CV Robinson, X Salvatella, CM Dobson, N Cremades
– PloS one
(2013)
8,
e67961
(doi: 10.1371/journal.pone.0067961)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
– Journal of molecular biology
(2013)
425,
2397
(doi: 10.1016/j.jmb.2013.01.040)
Single molecule fluorescence approach to investigate alpha-synuclein oligomer formation
L Tosatto, MH Horrocks, N Cremades, T Guilliams, M Dalla Serra, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2013)
42,
S189
(link to publication)
Using single molecule techniques to find out how the major protein associated with Parkinson's disease
MH Horrocks, L Tosatto, N Cremades, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2013)
42,
S188
(link to publication)
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
– Cell
(2012)
149,
1048
(doi: 10.1016/j.cell.2012.03.037)
Investigating the Factors Affecting the Aggregation of Alpha-Synuclein using Single Molecule Fluorescence and Fast Flow Microfluidics
MH Horrocks, N Cremades, L Tosatto, T Guilliams, E De Genst, J-U Shim, CM Dobson, D Klenerman
– Biophysical Journal
(2012)
102,
255A
(doi: 10.1016/j.bpj.2011.11.1407)
Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme
B Zambelli, N Cremades, P Neyroz, P Turano, VN Uversky, S Ciurli
– Mol. BioSyst.
(2011)
8,
220
(doi: 10.1039/c1mb05227f)
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