Centre for Misfolding Diseases

Dr Nunilo Cremades

Research Fellow

Publications

Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
PROTEIN SCIENCE
(2015)
24
Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
PloS one
(2014)
9
(doi: 10.1371/journal.pone.0087133)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
Journal of Molecular Biology
(2013)
425
(doi: 10.1016/j.jmb.2013.01.040)
Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, CV Robinson, X Salvatella, CM Dobson, N Cremades
PloS one
(2013)
8
(doi: 10.1371/journal.pone.0067961)
Single molecule fluorescence approach to investigate alpha-synuclein oligomer formation
L Tosatto, MH Horrocks, N Cremades, T Guilliams, M Dalla Serra, D Klenerman
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2013)
42
Using single molecule techniques to find out how the major protein associated with Parkinson's disease
MH Horrocks, L Tosatto, N Cremades, CM Dobson, D Klenerman
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2013)
42
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
Cell
(2012)
149
(doi: 10.1016/j.cell.2012.03.037)
Investigating the Factors Affecting the Aggregation of Alpha-Synuclein using Single Molecule Fluorescence and Fast Flow Microfluidics
MH Horrocks, N Cremades, L Tosatto, T Guilliams, E De Genst, J-U Shim, CM Dobson, D Klenerman
Biophysical Journal
(2012)
102
(doi: 10.1016/j.bpj.2011.11.1407)
Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme.
B Zambelli, N Cremades, P Neyroz, P Turano, VN Uversky, S Ciurli
Molecular Biosystems
(2011)
8
(doi: 10.1039/c1mb05227f)
Insights into the molecular mechanisms of Hsp70-mediated inhibition of amyloid formation
FA Aprile, A Dhulesia, F Stengel, T Eliseo, C Roodvelt, B Bolognesi, P Tortora, X Salvatella, N Cremades, CM Dobson
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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