Research Associate

I am a post-doctoral researcher supported by the Schmidt Science Foundation in partnership with the Rhodes Trust and a fellow at St. John's College. My research focusses on developing new experimental and predictive computational methods for examining the behaviour of biological molecules and systems, in particular proteins.

Proteins are the executive molecules of life that through diverse set of highly integrated and tightly regulated interactions set the molecular basis for our well-being. Yet the diverse and dynamic nature of proteins has made it challenging to devise methods that could be effectively used for understanding the roles of proteins in human health and disease. As part of my research, I bring the state-of-the-art micron and nano scale fabrication and flow engineering approaches that I developed during my PhD research together with single molecule optical tools and machine-learning based computational approaches to develop methods for understanding the diversity of the biological roles of proteins. One of my key interests is to develop an explorative probe-free platform for single cell proteomic analysis.

My personal website: http://www.kadiliissaar.com/

Publications

Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.
WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, TPJ Knowles
Analytical Chemistry
(2018)
90
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal of neuroscience methods
(2018)
306
Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
Analytical chemistry
(2018)
90
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
Analytical chemistry
(2018)
90
Microfluidic approaches for probing amyloid assembly and behaviour
TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
Lab on A Chip
(2018)
18
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion
Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles
Chem Sci
(2018)
9
Enhancing power density of biophotovoltaics by decoupling storage and power delivery
KL Saar, P Bombelli, DJ Lea-Smith, T Call, EM Aro, T Müller, CJ Howe, TPJ Knowles
Nature Energy
(2018)
3
Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements
L Kong, KL Saar, R Jacquat, L Hong, A Levin, H Gang, R Ye, B Mu, TPJ Knowles
Interface focus
(2017)
7
Gradient-free determination of isoelectric points of proteins on chip
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, T Knowles
Phys Chem Chem Phys
(2017)
19
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, X Yang, S Linse, TPJ Knowles
Lab on a chip
(2017)
18

Postdoctoral researcher

Telephone number

01223 336359

Email address