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Centre for Misfolding Diseases

Gabriella (Gabi) Heller is the Rosalind Franklin Research Fellow at Newnham College. Her research focuses on intrinsically disordered proteins, biomolecules lacking a single, rigid three-dimensional structure that instead exist as a dynamic equilibrium of conformationally distinct states. These proteins are highly prevalent in diseases such as dementia and cancer, yet are often considered therapeutically 'untargetable' as they are unamenable to traditional drug discovery techniques.  Gabriella aims to understand whether and how intrinsically disordered proteins can be targeted by small molecule therapeutics using a combination of computational and experimental techniques. 

Publications

A small molecule stabilises the disordered native state of the Alzheimer’s Aβ peptide
T Löhr, K Kohlhoff, G Heller, C Camilloni, M Vendruscolo
(2021)
2021.11.10.468059
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, IC Felli, R Pierattelli, TPJ Knowles, CM Dobson, M Vendruscolo
– Sci Adv
(2020)
6,
eabb5924
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles
– Proc Natl Acad Sci U S A
(2020)
117,
24251
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2020)
117,
13509
A kinetic ensemble of the Alzheimer’s Aβ peptide
T Löhr, K Kohlhoff, G Heller, C Camilloni, M Vendruscolo
(2020)
2020.05.07.082818
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
225
Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo
(2019)
729392
Promoting transparency and reproducibility in enhanced molecular simulations
PLUMED consortium
– Nature Methods
(2019)
16,
670
Determination of Structural Ensembles of Proteins: Restraining vs Reweighting
R Rangan, M Bonomi, GT Heller, A Cesari, G Bussi, M Vendruscolo
– J Chem Theory Comput
(2018)
14,
6632
A structural ensemble modulation mechanism of small molecule binding to disordered proteins
GT Heller, M Bonomi, M Vendruscolo
– J Mol Biol
(2018)
430,
2288
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01223 763842

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