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Centre for Misfolding Diseases

Research Associate

 

Education

​2016 - PhD in Biophysical Chemistry, University of Cambridge

2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge

2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology

 

Research Interests

Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening

 

Selected Publications

 

Publications

Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease
G Meisl, Y Zuo, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, T Knowles, D Klenerman
– Alzheimer's & Dementia
(2022)
17,
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
MM Schneider, M Emmenegger, CK Xu, I Condado Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RP Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TP Knowles, A Aguzzi
– Life Science Alliance
(2021)
5,
e202101270
Proliferation of Tau 304–380 Fragment Aggregates through Autocatalytic Secondary Nucleation
DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, SIA Cohen, G Meisl, J Habchi, TPJ Knowles, M Vendruscolo, S Linse
– ACS Chemical Neuroscience
(2021)
12,
4406
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates
DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, M Lundqvist, C Pohl, K Bernfur, V Lattanzi, J Habchi, SI Cohen, TPJ Knowles, M Vendruscolo, S Linse
– Frontiers in molecular biosciences
(2021)
8,
757425
In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease
G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman
– Science Advances
(2021)
7,
eabh1448
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules
D Zaguri, MR Zimmermann, G Meisl, A Levin, S Rencus-Lazar, TPJ Knowles, E Gazit
– ACS nano
(2021)
15,
18305
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation.
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
– J Am Chem Soc
(2021)
143,
16621
A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, R Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, M Holt, L Simonelli, L Varani, A Aguzzi
(2021)
2021.09.20.460912
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, G Meisl, QAE Peter, TW Herling, S Ness, M Castellana-Cruz, JLP Benesch, M Vendruscolo, CM Dobson, P Arosio, TPJ Knowles
– Proc Natl Acad Sci U S A
(2021)
118,
e2108790118
Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers.
SE Sanchez, DR Whiten, G Meisl, FS Ruggeri, E Hidari, D Klenerman
– Chembiochem
(2021)
22,
2867
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Postdoctoral researcher

Telephone number

01223 763842

Email address