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Centre for Misfolding Diseases

Research Associate

 

Education

​2016 - PhD in Biophysical Chemistry, University of Cambridge

2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge

2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology

 

Research Interests

Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening

 

Selected Publications

 

Publications

Mechanism of secondary nucleation from the direct observation of Aβ42 aggregation at the single fibril level
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
– Biophysical Journal
(2022)
121,
443a
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease
G Meisl, Y Zuo, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, T Knowles, D Klenerman
– Alzheimer's & Dementia
(2022)
17,
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
MM Schneider, M Emmenegger, CK Xu, I Condado Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RP Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TP Knowles, A Aguzzi
– Life science alliance
(2021)
5,
e202101270
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation
DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, SIA Cohen, G Meisl, J Habchi, TPJ Knowles, M Vendruscolo, S Linse
– ACS chemical neuroscience
(2021)
12,
4406
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates
DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, M Lundqvist, C Pohl, K Bernfur, V Lattanzi, J Habchi, SI Cohen, TPJ Knowles, M Vendruscolo, S Linse
– Frontiers in Molecular Biosciences
(2021)
8,
757425
In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease
G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman
– Sci Adv
(2021)
7,
eabh1448
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules.
D Zaguri, MR Zimmermann, G Meisl, A Levin, S Rencus-Lazar, TPJ Knowles, E Gazit
– ACS nano
(2021)
15,
18305
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of A beta 42 Aggregation
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
– Journal of the American Chemical Society
(2021)
143,
16621
A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, R Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, M Holt, L Simonelli, L Varani, A Aguzzi
(2021)
2021.09.20.460912
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.
T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, G Meisl, QAE Peter, TW Herling, S Ness, M Castellana-Cruz, JLP Benesch, M Vendruscolo, CM Dobson, P Arosio, TPJ Knowles
– Proceedings of the National Academy of Sciences
(2021)
118,
e2108790118
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Postdoctoral researcher

Telephone number

01223 763842

Email address