Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
Origin of metastable oligomers and their effects on amyloid fibril self- assembly
Chemical science
(2018)
9
5937
(doi: 10.1039/c8sc01479e)
On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
Proceedings of the National Academy of Sciences of the United States of America
(2018)
115
E5849
(doi: 10.1073/pnas.1803539115)
Kinetic Analysis of Amyloid Formation
Methods in molecular biology (Clifton, N.J.)
(2018)
1779
181
(doi: 10.1007/978-1-4939-7816-8_12)
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
ACS Chem Neurosci
(2018)
9
1276
(doi: 10.1021/acschemneuro.8b00094)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
Annual review of physical chemistry
(2018)
69
1
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.
Anal Chem
(2018)
90
3284
(doi: 10.1021/acs.analchem.7b04820)
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.
Chem Sci
(2018)
9
3503
(doi: 10.1039/c7sc04331g)
Secondary nucleation in amyloid formation
Chemical communications (Cambridge, England)
(2018)
54
8667
(doi: 10.1039/c8cc02204f)
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.
Chemical communications (Cambridge, England)
(2018)
54
7854
(doi: 10.1039/c8cc03002b)
Absolute Quantification of Amyloid Propagons by Digital Microfluidics
Analytical chemistry
(2017)
89
12306
(doi: 10.1021/acs.analchem.7b03279)
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